Application | Comment | Organism |
---|---|---|
additional information | NADPH oxidase but not myeloperoxidase is required for host defense in lymphopenic mice. Lymphocytes and NADPH oxidase may compensate for each other's deficiency in providing resistance to spontaneous bacterial infections | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | neither mice lacking subunit gp91, lacking myeloperoxidase, nor lymphocyte-deficient recombinase activating gene-1 ko mice develop spontaneous infections when raised under specific pathogen-free conditions and all mice have life spans similar to wild-type animals. Subunit gp91/recombinase activating gene-1 double-deficient but not myeloperoxidase/recombinase activating gene-1 double-deficient mice develop spontaneous multi-organ bacterial and fungal infections early in life and live only a few months. Infections in the gp91/recombinase activating gene-1 double-deficient mice are characterized by granulomatous inflammation of the skin, liver, heart, brain, kidney, and lung. Oyster glycogen-elicited polymorphonuclear neutrophils and macrophages obtained from gp91 ko and gp91/recombinase activating gene-1 double-deficient mice have no detectable NADPH oxidase activity whereas wild-type, recombinase activating gene-1 ko, and myeloperoxidase/recombinase activating gene-1 polymorphonuclear neutrophils and macrophages produce large and similar amounts of superoxide in response to phorbol myristate acetate | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |