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Literature summary for 1.6.3.1 extracted from

  • Choi, S.I.; Jeong, C.S.; Cho, S.Y.; Lee, Y.S.
    Mechanism of apoptosis induced by apigenin in HepG2 human hepatoma cells: involvement of reactive oxygen species generated by NADPH oxidase (2007), Arch. Pharm. Res., 30, 1328-1335.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
apigenin apigenin reduces cell viability, and induces apoptotic cell death in a dose-dependent manner. In addition, it evokes a dose-related elevation of intracellular reactive oxygen species level. Treatment with various inhibitors of the NADPH oxidase significantly blunts both the generation of reactive oxygen species and induction of apoptosis induced by apigenin Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
apocynin significantly blunts both the generation of reactive oxygen species and induction of apoptosis induced by apigenin Homo sapiens
diphenylene iodonium significantly blunts both the generation of reactive oxygen species and induction of apoptosis induced by apigenin Homo sapiens
neopterin significantly blunts both the generation of reactive oxygen species and induction of apoptosis induced by apigenin Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
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Homo sapiens
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