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Literature summary for 1.6.3.1 extracted from

  • Steffen, Y.; Gruber, C.; Schewe, T.; Sies, H.
    Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase (2008), Arch. Biochem. Biophys., 469, 209-219.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(-)-epicatechin glucuronide acts both as a superoxide anion scavenger,and inhibitory to NAD(P)H oxidase, with apocynin-like mode of NADPH oxidase inhibition Homo sapiens
3'-(or 4'-)methylluteolin
-
Homo sapiens
3'-O-methyl epicatechin
-
Homo sapiens
4'-O-methyl epicatechin
-
Homo sapiens
COMT-methylated procyanidin B2
-
Homo sapiens
dihydrokaempferol
-
Homo sapiens
dihydrotamarixetin
-
Homo sapiens
diosmetin
-
Homo sapiens
epicatechin gallate
-
Homo sapiens
epigallocatechin
-
Homo sapiens
epigallocatechin gallate
-
Homo sapiens
ferulic acid
-
Homo sapiens
hesperetin
-
Homo sapiens
isorhamnetin
-
Homo sapiens
isorhamnetin glucuronide
-
Homo sapiens
additional information epicatechin is a superoxide anion scavenger, but not inhibitory to NAD(P)H oxidase. HUVEC cells are able to convert (-)-epicatechin to its inhibitory O-methyl esters. IC50-values of (-)epicatechin and (+)catechin are above 0.1 mM in cell lysates Homo sapiens
naringenin
-
Homo sapiens
procyanidin B2 acts both as a superoxide anion scavenger, and inhibitory to NAD(P)H oxidase, with apocynin-like mode of NADPH oxidase inhibition Homo sapiens
quercetin glucuronide
-
Homo sapiens
tamarixetin
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HUVEC cell
-
Homo sapiens
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0028
-
25°C, pH 7.4, cell lysate Homo sapiens isorhamnetin
0.0035
-
25°C, pH 7.4, cell lysate Homo sapiens epigallocatechin gallate
0.0038
-
25°C, pH 7.4, cell lysate Homo sapiens procyanidin B2
0.0041
-
25°C, pH 7.4, cell lysate Homo sapiens dihydrotamarixetin
0.0045
-
25°C, pH 7.4, cell lysate Homo sapiens COMT-methylated procyanidin B2
0.0049
-
25°C, pH 7.4, cell lysate Homo sapiens ferulic acid
0.0049
-
25°C, pH 7.4, cell lysate Homo sapiens dihydrokaempferol
0.0049
-
25°C, pH 7.4, cell lysate Homo sapiens (-)-epicatechin glucuronide
0.0049
-
25°C, pH 7.4, cell lysate Homo sapiens quercetin glucuronide
0.0049
-
25°C, pH 7.4, cell lysate Homo sapiens isorhamnetin glucuronide
0.0061
-
25°C, pH 7.4, cell lysate Homo sapiens 3'-(or 4'-)methylluteolin
0.0074
-
25°C, pH 7.4, cell lysate Homo sapiens hesperetin
0.0074
-
25°C, pH 7.4, cell lysate Homo sapiens tamarixetin
0.0076
-
25°C, pH 7.4, cell lysate Homo sapiens diosmetin
0.0079
-
25°C, pH 7.4, cell lysate Homo sapiens naringenin
0.0079
-
25°C, pH 7.4, cell lysate Homo sapiens 3'-O-methyl epicatechin
0.008
-
25°C, pH 7.4, cell lysate Homo sapiens epigallocatechin
0.015
-
25°C, pH 7.4, cell lysate Homo sapiens epicatechin gallate
0.0207
-
25°C, pH 7.4, cell lysate Homo sapiens 4'-O-methyl epicatechin