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Literature summary for 1.6.3.1 extracted from

  • Banfi, B.; Malgrange, B.; Knisz, J.; Steger, K.; Dubois-Dauphin, M.; Krause, K.H.
    NOX3, a superoxide-generating NADPH oxidase of the inner ear (2004), J. Biol. Chem., 279, 46065-46072.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
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Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADPH + H+ + O2 Rattus norvegicus NOX3 is a relevant source of reactive oxygen species generation in the cochlear and vestibular systems. NOX3-dependent ROS generation might contribute to hearing loss and balance problems in response to ototoxic drugs NADP+ + H2O2
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?
NADPH + H+ + O2 Mus musculus NOX3 is a relevant source of reactive oxygen species generation in the cochlear and vestibular systems. NOX3-dependent ROS generation might contribute to hearing loss and balance problems in response to toxic drugs NADP+ + H2O2
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?

Organism

Organism UniProt Comment Textmining
Mus musculus Q672J9
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Rattus norvegicus Q672K1
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-

Source Tissue

Source Tissue Comment Organism Textmining
brain low amounts of NOX3 Mus musculus
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inner ear cochlear and vestibular system, NOX3 is highly expressed in specific portions of the inner ear Mus musculus
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inner ear cochlear and vestibular system, NOX3 is highly expressed in specific portions of the inner ear Rattus norvegicus
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kidney embryonic, low amounts of NOX3 Mus musculus
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skull low amounts of NOX3 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + H+ + O2
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Mus musculus NADP+ + H2O2
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?
NADPH + H+ + O2
-
Rattus norvegicus NADP+ + H2O2
-
?
NADPH + H+ + O2 NOX3 is a relevant source of reactive oxygen species generation in the cochlear and vestibular systems. NOX3-dependent ROS generation might contribute to hearing loss and balance problems in response to ototoxic drugs Rattus norvegicus NADP+ + H2O2
-
?
NADPH + H+ + O2 NOX3 is a relevant source of reactive oxygen species generation in the cochlear and vestibular systems. NOX3-dependent ROS generation might contribute to hearing loss and balance problems in response to toxic drugs Mus musculus NADP+ + H2O2
-
?

Synonyms

Synonyms Comment Organism
NOX3
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Mus musculus
NOX3
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Rattus norvegicus
superoxide-generating NADPH oxidase
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Mus musculus
superoxide-generating NADPH oxidase
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Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
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Mus musculus
NADPH
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Rattus norvegicus