Cloned (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADPH + H+ + O2 | Rattus norvegicus | NOX3 is a relevant source of reactive oxygen species generation in the cochlear and vestibular systems. NOX3-dependent ROS generation might contribute to hearing loss and balance problems in response to ototoxic drugs | NADP+ + H2O2 | - |
? | |
NADPH + H+ + O2 | Mus musculus | NOX3 is a relevant source of reactive oxygen species generation in the cochlear and vestibular systems. NOX3-dependent ROS generation might contribute to hearing loss and balance problems in response to toxic drugs | NADP+ + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q672J9 | - |
- |
Rattus norvegicus | Q672K1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | low amounts of NOX3 | Mus musculus | - |
inner ear | cochlear and vestibular system, NOX3 is highly expressed in specific portions of the inner ear | Mus musculus | - |
inner ear | cochlear and vestibular system, NOX3 is highly expressed in specific portions of the inner ear | Rattus norvegicus | - |
kidney | embryonic, low amounts of NOX3 | Mus musculus | - |
skull | low amounts of NOX3 | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADPH + H+ + O2 | - |
Mus musculus | NADP+ + H2O2 | - |
? | |
NADPH + H+ + O2 | - |
Rattus norvegicus | NADP+ + H2O2 | - |
? | |
NADPH + H+ + O2 | NOX3 is a relevant source of reactive oxygen species generation in the cochlear and vestibular systems. NOX3-dependent ROS generation might contribute to hearing loss and balance problems in response to ototoxic drugs | Rattus norvegicus | NADP+ + H2O2 | - |
? | |
NADPH + H+ + O2 | NOX3 is a relevant source of reactive oxygen species generation in the cochlear and vestibular systems. NOX3-dependent ROS generation might contribute to hearing loss and balance problems in response to toxic drugs | Mus musculus | NADP+ + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NOX3 | - |
Mus musculus |
NOX3 | - |
Rattus norvegicus |
superoxide-generating NADPH oxidase | - |
Mus musculus |
superoxide-generating NADPH oxidase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Mus musculus | |
NADPH | - |
Rattus norvegicus |