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Literature summary for 1.6.3.1 extracted from

  • Gorin, Y.; Leseney, A.M.; Ohayon, R.; Dupuy, C.; Pommier, J.; Virion, A.; Deme, D.
    Regulation of the thyroid NADPH-dependent H2O2 generator by Ca2+: studies with phenylarsine oxide in thyroid plasma membrane (1997), Biochem. J., 321, 383-388.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
alpha-chymotrypsin desensitization of activity to Ca2+ Sus scrofa
Phenylarsine oxide partial inactivation and desensitization of activity to Ca2+, effect is completely reversed by addition of 2,3-dimercaptopropanol Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
apical plasma membrane
-
Sus scrofa 16324
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ regulates enzyme activity Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD(P)H + H+ + O2 Sus scrofa production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis NAD(P)+ + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
thyroid gland
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD(P)H + H+ + O2
-
Sus scrofa NAD(P)+ + H2O2
-
?
NAD(P)H + H+ + O2 production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis Sus scrofa NAD(P)+ + H2O2
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.003
-
Phenylarsine oxide 3 nmol/mg protein Sus scrofa