Literature summary for 1.6.3.1 extracted from

Carvalho, D.P.; Dupuy, C.; Gorin, Y.; Legue, O.; Pommier, J.; Haye, B.; Virion, A.
The Ca2+- and reduced nicotinamide adenine dinucleotide phosphate-dependent hydrogen peroxide generating system is induced by thyrotropin in porcine thyroid cells (1996), Endocrinology, 137, 1007-1012.

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Activating Compound

Activating Compound	Comment	Organism	Structure
8-bromo-cAMP	can replace for thyrotropin	Sus scrofa
forskolin	can replace thyrotropin	Sus scrofa
additional information	upregulated by agents activationg cAMP pathway	Sus scrofa
thyrotropin	almost no activity in cells grown without	Sus scrofa

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.015	-	NADPH	pH 7.2, 30°C, 1.5 mM Ca2+	Sus scrofa

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	regulates enzyme activity	Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NAD(P)H + H+ + O2	Sus scrofa	production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis	NAD(P)+ + H2O2	-	?

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
thyroid gland	-	Sus scrofa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD(P)H + H+ + O2	-	Sus scrofa	NAD(P)+ + H2O2	-	?
NAD(P)H + H+ + O2	production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis	Sus scrofa	NAD(P)+ + H2O2	-	?

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Release 2023.1 (January 2023)