Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.6.3.1 extracted from

  • Dupuy, C.; Virion, A.; Hammou, N.A.; Kaniewski, J.; Deme, D.; Pommier, J.
    Solubilization and characteristics of the thyroid NADPH-dependent hydrogen peroxide generating system (1986), Biochem. Biophys. Res. Commun., 141, 839-846.
    View publication on PubMed

General Stability

General Stability Organism
CHAPS is the best detergent for solubilization of enzyme, preserves native properties of enzyme Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
DTNB
-
Sus scrofa
EGTA almost complete inhibition at 0.5 mM Sus scrofa
N-ethylmaleimide weak inhibition Sus scrofa
p-hydroxymercuribenzoate
-
Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
apical plasma membrane
-
Sus scrofa 16324
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required for full activity Sus scrofa
Ca2+ regulates enzyme activity Sus scrofa
Cd2+ can replace for Ca2+ Sus scrofa
additional information Mg2+ has no effect Sus scrofa
Zn2+ can replace for Ca2+ Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD(P)H + H+ + O2 Sus scrofa production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis NAD(P)+ + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
thyroid gland
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD(P)H + H+ + O2
-
Sus scrofa NAD(P)+ + H2O2
-
?
NAD(P)H + H+ + O2 production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis Sus scrofa NAD(P)+ + H2O2
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 8
-
Sus scrofa