Activating Compound | Comment | Organism | Structure |
---|---|---|---|
phosphate | - |
Homo sapiens | |
phosphate | - |
Sus scrofa | |
thyrotropin | - |
Homo sapiens | |
thyrotropin | - |
Sus scrofa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | unidentified inhibitor found in 3000 g particulate fraction from patients with Grave's disease | Homo sapiens | |
additional information | - |
Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.01 | - |
NADPH | pH 7.4, 30°C, 1.5 mM Ca2+ | Sus scrofa | |
0.1 | - |
NADPH | pH 7.4, 30°C, 1.5 mM Ca2+, patients with Grave's disease | Homo sapiens | |
0.1 | - |
NADH | pH 7.4, 30°C, 1.5 mM Ca2+, patients with Grave's disease | Homo sapiens | |
0.2 | - |
NADH | pH 7.4, 30°C, 1.5 mM Ca2+ | Sus scrofa |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | regulates enzyme activity | Homo sapiens | |
Ca2+ | regulates enzyme activity | Sus scrofa | |
Ca2+ | no activity without | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD(P)H + H+ + O2 | Homo sapiens | production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis | NAD(P)+ + H2O2 | - |
? | |
NAD(P)H + H+ + O2 | Sus scrofa | production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis | NAD(P)+ + H2O2 | - |
? | |
NAD(P)H + H+ + O2 | Homo sapiens | involved in Grave's disease | NAD(P)+ + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
female | - |
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
thyroid gland | - |
Homo sapiens | - |
thyroid gland | - |
Sus scrofa | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.002 | - |
pH 7.4, 30°C, 1.5 mM Ca2+, saturating concentration of NADPH | Sus scrofa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD(P)H + H+ + O2 | - |
Homo sapiens | NAD(P)+ + H2O2 | - |
? | |
NAD(P)H + H+ + O2 | - |
Sus scrofa | NAD(P)+ + H2O2 | - |
? | |
NAD(P)H + H+ + O2 | production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis | Homo sapiens | NAD(P)+ + H2O2 | - |
? | |
NAD(P)H + H+ + O2 | production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis | Sus scrofa | NAD(P)+ + H2O2 | - |
? | |
NAD(P)H + H+ + O2 | involved in Grave's disease | Homo sapiens | NAD(P)+ + H2O2 | - |
? | |
NADH + H+ + O2 | - |
Homo sapiens | NAD+ + H2O2 | - |
? | |
NADH + H+ + O2 | - |
Sus scrofa | NAD+ + H2O2 | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens | |
FAD | - |
Sus scrofa | |
FMN | can replace for FAD | Homo sapiens | |
NADH | can replace NADPH | Homo sapiens | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Sus scrofa |