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Literature summary for 1.6.2.4 extracted from
- Involvement of microsomal NADPH-cytochrome P450 reductase in metabolic reduction of drug ketones (2015), Biopharm. Drug Dispos., 36, 398-404 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha-lipoic acid | 17% inhibition at 5.0 mM | Homo sapiens |  |
| Ethacrynic acid | 64% inhibition at 1.0 mM | Homo sapiens | |
| menadione | 85% inhibition at 0.2 mM | Homo sapiens | |
| additional information | no significant inhibition by diphenyleneiodonium chloride, flufenamic acid, and 18beta-glycyrrhetinic acid | Homo sapiens | |
| phenolphthaleine | 13% inhibition at 0.02 mM | Homo sapiens | |
| quercetin | 48% inhibition at 0.2 mM | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NADPH + H+ + 1-[3-(4-phenoxyphenoxy)-2-oxopropyl]indole-5-carboxylic acid | - |
Homo sapiens | NADP+ + 1-[2-hydroxy-3-(4-phenoxyphenoxy)propyl]indole-5-carboxylic acid | - |
? | |
| NADPH + H+ + daunorubicin | - |
Homo sapiens | NADP+ + ? | - |
? | |
| NADPH + H+ + haloperidol | - |
Homo sapiens | NADP+ + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NADPH-CYP450 reductase | - |
Homo sapiens |
| NADPH-cytochrome P450 reductase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Homo sapiens | |
| FMN | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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