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Literature summary for 1.6.2.4 extracted from

  • Zhou, X.; Li, M.; Sheng, C.; Qiu, X.
    NADPH-cytochrome P450 oxidoreductase from the chicken (Gallus gallus): sequence characterization, functional expression and kinetic study (2011), Comp. Biochem. Physiol. C, 153, 53-59.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, sequence comparisons, the enzyme shows highly conserved exon/intron organization structure, functional expression in Escherichia coli membranes Gallus gallus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetic mechanism, overview Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADPH + H+ + cytochrome c Gallus gallus
-
NADP+ + reduced cytochrome c
-
?

Organism

Organism UniProt Comment Textmining
Gallus gallus F1P2T2
-
-

Reaction

Reaction Comment Organism Reaction ID
NADPH + oxidized hemoprotein = NADP+ + reduced hemoprotein + H+ kinetic mechanism, overview Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + H+ + cytochrome c
-
Gallus gallus NADP+ + reduced cytochrome c
-
?

Synonyms

Synonyms Comment Organism
NADPH-cytochrome P450 oxidoreductase
-
Gallus gallus
POR
-
Gallus gallus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Gallus gallus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.7
-
assay at Gallus gallus

Cofactor

Cofactor Comment Organism Structure
FAD
-
Gallus gallus
FMN
-
Gallus gallus
NADPH
-
Gallus gallus

General Information

General Information Comment Organism
evolution chicken POR shares high homology with other vertebrates PORs and possesses the conserved binding domains of FAD, FMN, and NADPH Gallus gallus