Literature summary for 1.6.2.4 extracted from

Martinez, V.G.; Williams, K.J.; Stratford, I.J.; Clynes, M.; OConnor, R.
Overexpression of cytochrome P450 NADPH reductase sensitises MDA 231 breast carcinoma cells to 5-fluorouracil: possible mechanisms involved (2008), Toxicol. In Vitro, 22, 582-588.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	P450R function is essential for cytochrome P450 activity. The enzyme provides the electrons used in P450-mediated reactions using NADPH as a cofactor. P450R-transfected MDA 231 breast cells display increased sensitivity to mitomycin C and 5-fluorouracil as compared to their empty-vector transfected counterparts. NADPH levels are decreased in P450R-overexpressing cells	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	P450R function is essential for cytochrome P450 activity. The enzyme provides the electrons used in P450-mediated reactions using NADPH as a cofactor. P450R-transfected MDA 231 breast cells display increased sensitivity to mitomycin C and 5-fluorouracil as compared to their empty-vector transfected counterparts. NADPH levels are decreased in P450R-overexpressing cells	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
cytochrome P450 NADPH reductase	-	Homo sapiens
P450R	-	Homo sapiens

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Release 2023.1 (January 2023)