Literature summary for 1.6.2.2 extracted from

Xiao, X.; Zhao, W.; Tian, F.; Zhou, X.; Zhang, J.; Huang, T.; Hou, B.; Du, C.; Wang, S.; Mo, Y.; Yu, N.; Zhou, S.; You, J.; Zhang, Z.; Huang, G.; Zeng, X.
Cytochrome b5 reductase 2 is a novel candidate tumor suppressor gene frequently inactivated by promoter hypermethylation in human nasopharyngeal carcinoma (2014), Tumour Biol., 35, 3755-3763 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NADH + ferricytochrome b5	Homo sapiens	-	NAD+ + H+ + ferrocytochrome b5	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
C666-1 cell	-	Homo sapiens	-
CNE-1 cell	-	Homo sapiens	-
CNE-2 cell	-	Homo sapiens	-
HNE-1 cell	-	Homo sapiens	-
HONE-1 cell	-	Homo sapiens	-
nasopharyngeal carcinoma cell	-	Homo sapiens	-
NPC-TW03 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NADH + ferricytochrome b5	-	Homo sapiens	NAD+ + H+ + ferrocytochrome b5	-	?

Synonyms

Synonyms	Comment	Organism
CYB5R2	-	Homo sapiens
cytochrome b5 reductase 2	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	enzyme transcript levels are decreased in nasopharyngeal carcinoma cell lines and tumor biopsies	down

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Release 2023.1 (January 2023)