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Literature summary for 1.6.2.2 extracted from

  • Kurian, J.R.; Chin, N.A.; Longlais, B.J.; Hayes, K.L.; Trepanier, L.A.
    Reductive detoxification of arylhydroxylamine carcinogens by human NADH cytochrome b5 reductase and cytochrome b5 (2006), Chem. Res. Toxicol., 19, 1366-1373.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine reduction of arylhydroxylamine carcinogens by enzyme and ferricytochrome b5 as a source of individual variability with respect to cancer susceptibility following exposure to arylhydroxylamines Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.22
-
N-Hydroxy-4-aminobiphenyl pH 7.4 Homo sapiens
0.25
-
N-hydroxy-2-amino-1-methyl-6-phenylimidazol[4,5-b]pyridine pH 7.4 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ferricytochrome b5 + N-hydroxy-2-amino-1-methyl-6-phenylimidazol[4,5-b]pyridine arylhydroxylamine carcinogen found in grilled meat Homo sapiens ferrocytochrome b5 + ?
-
?
ferricytochrome b5 + N-hydroxy-4-aminobiphenyl arylhydroxylamine carcinogen found in cigarette smoke Homo sapiens ferrocytochrome b5 + ?
-
?