Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADPH + NAD+ | Rattus norvegicus | - |
NADP+ + NADH | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
N-27 cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADPH + 3-acetylpyridine adenine dinucleotide | - |
Rattus norvegicus | NADP+ + reduced 3-acetylpyridine adenine dinucleotide | - |
? | |
NADPH + NAD+ | - |
Rattus norvegicus | NADP+ + NADH | - |
? |
Synonyms | Comment | Organism |
---|---|---|
nicotinamide nucleotide transhydrogenase | - |
Rattus norvegicus |
NNT | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inhibition decreases NADPH levels, decreases thioredoxin and thioredoxin reductase activity, and increases toxicity to oxidative stress | Rattus norvegicus |
physiological function | the enzyme links mitochondrial respiration and antioxidant activity in brain mitochondria | Rattus norvegicus |