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Literature summary for 1.6.1.2 extracted from
- Mitochondrial NADPH transhydrogenase and disease (2006), Biochim. Biophys. Acta, 1757, 721-726.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | diabetes is potentially linked to a defective transhydrogenase gene | ? | - |
? |  |
| NADH + NADP+ | Caenorhabditis elegans | the enzyme protects against methylviologen-dependent oxidative stress. Through a high GSH/GSSG ratio, transhydrogenase-generated NADPH contributes to a detoxification of peroxides formed from superoxide and lipid peroxidation | NADPH + NAD+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Caenorhabditis elegans | - |
- |
- |
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | diabetes is potentially linked to a defective transhydrogenase gene | Mus musculus | ? | - |
? | |
| NADH + NADP+ | the enzyme protects against methylviologen-dependent oxidative stress. Through a high GSH/GSSG ratio, transhydrogenase-generated NADPH contributes to a detoxification of peroxides formed from superoxide and lipid peroxidation | Caenorhabditis elegans | NADPH + NAD+ | - |
? | |
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