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Literature summary for 1.5.99.B2 extracted from

  • Kim, K.Y.; Ahn, J.H.; Cheon, H.G.
    Apoptotic action of peroxisome proliferator-activated receptor-gamma activation in human non small-cell lung cancer is mediated via proline oxidase-induced reactive oxygen species formation (2007), Mol. Pharmacol., 72, 674-685.
    View publication on PubMed
Search for more literature for 1.5.99.B2

Activating Compound

Activating Compound Comment Organism Structure
additional information POX mRNA expression, and the extent of POX induction is correlated with radical oxygen species level and cell death suggesting that POX-induced radical oxygen species formation is critical for the apoptotic cell death induced by PPARgamma activation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
lung adenocarcinoma cell
-
 Homo sapiens
-
NCI-H460 cell
-
 Homo sapiens
-
NCI-H596 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-proline + acceptor + H2O
-
 Homo sapiens (S)-1-pyrroline-5-carboxylate + reduced acceptor
-
 ?

Synonyms

Synonyms Comment Organism
POX
-
 Homo sapiens