Literature summary for 1.5.99.B2 extracted from

Hu, C.A.; Donald, S.P.; Yu, J.; Lin, W.W.; Liu, Z.; Steel, G.; Obie, C.; Valle, D.; Phang, J.M.
Overexpression of proline oxidase induces proline-dependent and mitochondria-mediated apoptosis (2007), Mol. Cell. Biochem., 295, 85-92.

Search for more literature for 1.5.99.B2

Activating Compound

Activating Compound	Comment	Organism	Structure
L-proline	in the presence of L-proline, high POX activity is sufficient to induce mitochondria-mediated apoptosis	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in DLD-1.POX cells	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colorectal cancer cell	-	Homo sapiens	-
DLD-1 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-proline + cytochrome c + H2O	-	Homo sapiens	(S)-1-pyrroline-5-carboxylate + reduced cytochrome c	-	?

Synonyms

Synonyms	Comment	Organism
POX	-	Homo sapiens
PRODH	-	Homo sapiens
proline dehydrogenase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Homo sapiens

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Release 2023.1 (January 2023)