Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-hydroxypseudooxynicotine + EtfAB + H2O | Agrobacterium tumefaciens | - |
6-hydroxy-3-succinoylsemialdehyde-pyridine + methylamine + reduced EtfAB | - |
? | |
6-hydroxypseudooxynicotine + EtfAB + H2O | Agrobacterium tumefaciens S33 | - |
6-hydroxy-3-succinoylsemialdehyde-pyridine + methylamine + reduced EtfAB | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agrobacterium tumefaciens | - |
- |
- |
Agrobacterium tumefaciens S33 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-hydroxypseudooxynicotine + 2,6-dichlorophenolindophenol + H2O | - |
Agrobacterium tumefaciens | 6-hydroxy-3-succinoylsemialdehyde-pyridine + methylamine + reduced 2,6-dichlorophenolindophenol | - |
? | |
6-hydroxypseudooxynicotine + 2,6-dichlorophenolindophenol + H2O | - |
Agrobacterium tumefaciens S33 | 6-hydroxy-3-succinoylsemialdehyde-pyridine + methylamine + reduced 2,6-dichlorophenolindophenol | - |
? | |
6-hydroxypseudooxynicotine + EtfAB + H2O | - |
Agrobacterium tumefaciens | 6-hydroxy-3-succinoylsemialdehyde-pyridine + methylamine + reduced EtfAB | - |
? | |
6-hydroxypseudooxynicotine + EtfAB + H2O | - |
Agrobacterium tumefaciens S33 | 6-hydroxy-3-succinoylsemialdehyde-pyridine + methylamine + reduced EtfAB | - |
? | |
additional information | no electron acceptors: NAD(P)+, O2, and ferredoxin | Agrobacterium tumefaciens | ? | - |
- |
|
additional information | no electron acceptors: NAD(P)+, O2, and ferredoxin | Agrobacterium tumefaciens S33 | ? | - |
- |
General Information | Comment | Organism |
---|---|---|
physiological function | 6-hydroxypseudooxynicotine dehydrogenase utilizes the electron transfer flavoprotein EtfAB as the physiological electron acceptor. The electrons are further transferred from the reduced EtfAB to coenzyme Q by the catalysis of electron transfer flavoprotein:ubiquinone oxidoreductase. Disruption of the EtfAB genes in the nicotine-degrading gene cluster decreases the growth rate of Agrobacter tumefaciens S33 on nicotine but not on 6-hydroxy-3-succinoylpyridine | Agrobacterium tumefaciens |