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Literature summary for 1.5.7.2 extracted from

  • Yan, Z.; Wang, M.; Ferry, J.G.
    A ferredoxin- and F420H2-dependent, electron-bifurcating, heterodisulfide reductase with homologs in the domains Bacteria and Archaea (2017), mBio, 8, e02285-16 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.5.7.2

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0064
-
 oxidized coenzyme F420 21°C, pH not specified in the publication Methanosarcina acetivorans

Organism

Organism UniProt Comment Textmining
Methanosarcina acetivorans Q8TM02 cf. EC 1.8.7.3
-
Methanosarcina acetivorans ATCC 35395 Q8TM02 cf. EC 1.8.7.3
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
oxidized coenzyme F420 + 2 reduced ferredoxin + 2 H+
-
 Methanosarcina acetivorans reduced coenzyme F420 + 2 oxidized ferredoxin
-
 ?
oxidized coenzyme F420 + 2 reduced ferredoxin + 2 H+
-
 Methanosarcina acetivorans ATCC 35395 reduced coenzyme F420 + 2 oxidized ferredoxin
-
 ?

Synonyms

Synonyms Comment Organism
ferredoxin/F(420)H(2)-dependent CoB-CoM heterodisulfide reductase subunit A
-
 Methanosarcina acetivorans
HdrA2
-
 Methanosarcina acetivorans

General Information

General Information Comment Organism
physiological function presence of an intersubunit electron transport pathway in heterodisulfide reductase HdrA2B2C2 dependent on ferredoxin or coenzyme F420 (F420H2) as an electron donor. HdrA2B2C2 catalyzes a thermodynamically favorable, flavin-based, coupling of the endergonic one-electron reduction of ferredoxin (E0 of ca. -520 mV) with F420H2 (E0 of -380 mV) to the exergonic reduction of CoMS-SCoB (E0 of -140 mV) Methanosarcina acetivorans