BRENDA - Enzyme Database show
show all sequences of 1.5.5.3

A novel function for hydroxyproline oxidase in apoptosis through generation of reactive oxygen species

Cooper, S.K.; Pandhare, J.; Donald, S.P.; Phang, J.M.; J. Biol. Chem. 283, 10485-10492 (2008)

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Homo sapiens
5739
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q9UF12
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
HCT-15 cell
-
Homo sapiens
-
HT-29 cell
-
Homo sapiens
-
LoVo cell
-
Homo sapiens
-
RKO cell
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
trans-4-hydroxy-L-proline + cytochrome c
-
742832
Homo sapiens
(3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + reduced cytochrome c
-
-
-
?
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Homo sapiens
5739
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
HCT-15 cell
-
Homo sapiens
-
HT-29 cell
-
Homo sapiens
-
LoVo cell
-
Homo sapiens
-
RKO cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
trans-4-hydroxy-L-proline + cytochrome c
-
742832
Homo sapiens
(3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + reduced cytochrome c
-
-
-
?
Expression
Organism
Commentary
Expression
Homo sapiens
adriamycin induces p53-mediated gene expression and markedly increases the catalytic activity of the enzyme
up
General Information
General Information
Commentary
Organism
physiological function
the enzyme plays a role in growth regulation, reactive oxygen species generation, and activation of the apoptotic cascade
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
physiological function
the enzyme plays a role in growth regulation, reactive oxygen species generation, and activation of the apoptotic cascade
Homo sapiens
Expression (protein specific)
Organism
Commentary
Expression
Homo sapiens
adriamycin induces p53-mediated gene expression and markedly increases the catalytic activity of the enzyme
up
Other publictions for EC 1.5.5.3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741620
Wu
Metabolism, nutrition, and re ...
Homo sapiens
Antioxid. Redox Signal.
FEHLT
0000
2017
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1
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1
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3
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1
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741999
Li
Metabolism of (13)C5-hydroxyp ...
Mus musculus
Biochim. Biophys. Acta
1862
233-239
2016
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-
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1
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1
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4
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1
1
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741855
Summitt
Proline dehydrogenase 2 (PROD ...
Homo sapiens
Biochem. J.
466
273-281
2015
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1
1
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5
4
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1
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2
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1
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5
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8
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4
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5
5
742832
Cooper
A novel function for hydroxyp ...
Homo sapiens
J. Biol. Chem.
283
10485-10492
2008
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-
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1
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1
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4
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4
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1
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1
1
1
1
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743217
Lowry
Hydroxyproline metabolism by ...
Rattus norvegicus
Metab. Clin. Exp.
34
955-961
1985
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742315
Carnie
Comparative and developmental ...
Rattus norvegicus
Comp. Biochem. Physiol. B
71
681-687
1982
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