BRENDA - Enzyme Database show
show all sequences of 1.5.5.3

Metabolism of (13)C5-hydroxyproline in mouse models of primary hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase

Li, X.; Knight, J.; Fargue, S.; Buchalski, B.; Guan, Z.; Inscho, E.W.; Liebow, A.; Fitzgerald, K.; Querbes, W.; Todd Lowther, W.; Holmes, R.P.; Biochim. Biophys. Acta 1862, 233-239 (2016)

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Mus musculus
5739
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
trans-4-hydroxy-L-proline + a quinone
Mus musculus
-
(3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + a quinol
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
trans-4-hydroxy-L-proline + a quinone
-
741999
Mus musculus
(3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + a quinol
-
-
-
?
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Mus musculus
5739
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
trans-4-hydroxy-L-proline + a quinone
Mus musculus
-
(3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + a quinol
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
trans-4-hydroxy-L-proline + a quinone
-
741999
Mus musculus
(3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + a quinol
-
-
-
?
General Information
General Information
Commentary
Organism
malfunction
enzyme knockdown alters glycolate and oxalate levels
Mus musculus
General Information (protein specific)
General Information
Commentary
Organism
malfunction
enzyme knockdown alters glycolate and oxalate levels
Mus musculus
Other publictions for EC 1.5.5.3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741620
Wu
Metabolism, nutrition, and re ...
Homo sapiens
Antioxid. Redox Signal.
FEHLT
0000
2017
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-
-
-
-
-
-
-
1
-
-
1
-
3
-
-
-
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-
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1
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-
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1
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1
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1
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-
-
-
-
-
-
-
-
-
-
-
-
741999
Li
Metabolism of (13)C5-hydroxyp ...
Mus musculus
Biochim. Biophys. Acta
1862
233-239
2016
-
-
-
-
-
-
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1
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1
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4
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2
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1
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2
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1
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1
1
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-
-
741855
Summitt
Proline dehydrogenase 2 (PROD ...
Homo sapiens
Biochem. J.
466
273-281
2015
-
1
1
-
-
-
5
4
-
-
-
1
-
2
-
-
1
-
-
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8
-
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4
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1
1
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3
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1
1
1
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3
5
1
4
-
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1
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1
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8
-
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4
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-
5
5
742832
Cooper
A novel function for hydroxyp ...
Homo sapiens
J. Biol. Chem.
283
10485-10492
2008
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1
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1
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4
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1
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4
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1
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-
1
1
1
1
-
-
743217
Lowry
Hydroxyproline metabolism by ...
Rattus norvegicus
Metab. Clin. Exp.
34
955-961
1985
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1
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2
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3
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1
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742315
Carnie
Comparative and developmental ...
Rattus norvegicus
Comp. Biochem. Physiol. B
71
681-687
1982
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1
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2
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1
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