Cloned (Comment) | Organism |
---|---|
RT-PCR enzyme expression analysis | Felis sp. |
Protein Variants | Comment | Organism |
---|---|---|
F231C | naturally occuring mutation, the feline patient-specific mutation c.692T>G (p.F231C) in enzyme ETFDH in feline ETFDH is completely conserved in eukaryotes, and is located on the apical surface of enzyme ETFDH, receiving electrons from electron-transferring flavoprotein (ETF) causing multiple acyl-CoA dehydrogenation deficiency (MADD) in the cat, phenotype, overview | Felis sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
reduced electron-transferring flavoprotein + ubiquinone | Felis sp. | - |
electron-transferring flavoprotein + ubiquinol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Felis sp. | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
reduced electron-transferring flavoprotein + ubiquinone | - |
Felis sp. | electron-transferring flavoprotein + ubiquinol | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | enzyme protein structure homology-modeling | Felis sp. |
Synonyms | Comment | Organism |
---|---|---|
ETF dehydrogenase | - |
Felis sp. |
ETF-ubiquinone oxidoreductase | - |
Felis sp. |
ETFDH | - |
Felis sp. |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ubiquinone | - |
Felis sp. |
General Information | Comment | Organism |
---|---|---|
malfunction | deficiency of ETF or ETFDH leads to dysfunction of acyl-CoA dehydrogenase, resulting in accumulation of long- and medium-chain fatty acids. Multiple acyl-CoA dehydrogenation deficiency (glutaric aciduria type II, MADD) occurs due to a mutation of electron transfer flavoprotein-dehydrogenase in a cat, that presented with symptoms characteristic of MADD including hypoglycemia, hyperammonemia, vomiting, diagnostic organic aciduria, and accumulation of medium- and long-chain fatty acids in plasma, phenotype, overview | Felis sp. |
additional information | enzyme protein structure homology-modeling, overview | Felis sp. |
physiological function | ETFDH transfer electrons from ETF to ubiquinone, which exists in the inner mitochondrial membrane and participates in electron transport system to produce ATP. In this process, electrons enter through the flavin center of ETFDH and exit via the 4Fe-4S cluster for delivery to ubiquinone | Felis sp. |