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Literature summary for 1.5.4.1 extracted from

  • Giordano, E.; Peluso, I.; Rendina, R.; Digilio, A.; Furia, M.
    The clot gene of Drosophila melanogaster encodes a conserved member of the thioredoxin-like protein superfamily (2003), Mol. Genet. Genomics, 268, 692-697.
    View publication on PubMed
Search for more literature for 1.5.4.1

Activating Compound

Activating Compound Comment Organism Structure
2-mercaptoethanol required for the in vitro assay Drosophila melanogaster

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-pyruvoyl-tetrahydropterin + glutathione Drosophila melanogaster essential step in the biosynthesis of red components of the flye's eye pigments drosopterins pyrimidodiazepine + glutathione disulfide
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q9VMQ9 gene clot
-

Reaction

Reaction Comment Organism Reaction ID
2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O = 6-pyruvoyltetrahydropterin + 2 glutathione active site contains the sequence Cys-Pro-Tyr-Cys Drosophila melanogaster
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-pyruvoyl-tetrahydropterin + glutathione essential step in the biosynthesis of red components of the flye's eye pigments drosopterins Drosophila melanogaster pyrimidodiazepine + glutathione disulfide
-
 ?
6-pyruvoyl-tetrahydropterin + glutathione
-
 Drosophila melanogaster pyrimidodiazepine + glutathione disulfide
-
 ?

Synonyms

Synonyms Comment Organism
additional information enzyme belongs to the thioredoxin-like protein superfamily Drosophila melanogaster