Literature summary for 1.5.3.5 extracted from

Decker, K.; Bleeg, H.
Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans (1965), Biochim. Biophys. Acta, 105, 313-324.

Search for more literature for 1.5.3.5

Inhibitors

Inhibitors	Comment	Organism	Structure
6-hydroxy-D-nicotine	50% inhibition at 0.18 mM	Paenarthrobacter nicotinovorans

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.02	-	6-hydroxy-L-nicotine	-	Paenarthrobacter nicotinovorans

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(S)-6-hydroxynicotine + H2O + O2	Paenarthrobacter nicotinovorans	-	1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + H2O2	-	?

Organism

Organism	UniProt	Comment	Textmining
Paenarthrobacter nicotinovorans	-	formerly Arthrobacter oxidans	-

Purification (Commentary)

Purification (Comment)	Organism
partially	Paenarthrobacter nicotinovorans

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(S)-6-hydroxynicotine + H2O + O2	-	Paenarthrobacter nicotinovorans	1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + H2O2	-	?
L-6-hydroxy-nor-nicotine + H2O + O2	-	Paenarthrobacter nicotinovorans	1-(6-hydroxypyrid-3-yl)-4-aminobutan-1-one + H2O2	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Paenarthrobacter nicotinovorans

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Paenarthrobacter nicotinovorans

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Release 2023.1 (January 2023)