Literature summary for 1.5.3.5 extracted from

Decker, K.; Dai, V.D.
Mechanism and specifcity of L- and D-6-hydroxynicotine oxidase (1967), Eur. J. Biochem., 3, 132-138.

Search for more literature for 1.5.3.5

Inhibitors

Inhibitors	Comment	Organism	Structure
6-hydroxy-D-nicotine	-	Paenarthrobacter nicotinovorans
DL-2-hydroxynicotine	-	Paenarthrobacter nicotinovorans
methylene blue	strong inhibitor	Paenarthrobacter nicotinovorans

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(S)-6-hydroxynicotine + H2O + O2	Paenarthrobacter nicotinovorans	-	1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + H2O2	transitional product is 6-hydroxy-N-methylmyosmine that hydrolyses spontaneously	?

Organism

Organism	UniProt	Comment	Textmining
Paenarthrobacter nicotinovorans	-	formerly Arthrobacter oxidans	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(S)-6-hydroxynicotine + H2O + O2	-	Paenarthrobacter nicotinovorans	1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + H2O2	transitional product is 6-hydroxy-N-methylmyosmine that hydrolyses spontaneously	?

pH Stability

pH Stability	pH Stability Maximum	Comment	Organism
5	-	very unstable below pH 5	Paenarthrobacter nicotinovorans

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Paenarthrobacter nicotinovorans

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.1	-	6-hydroxy-D-nicotine	-	Paenarthrobacter nicotinovorans
0.31	-	DL-2-hydroxynicotine	-	Paenarthrobacter nicotinovorans

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Release 2023.1 (January 2023)