Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.5.3.4 extracted from

  • Kim, S.; Benoiton, L.; Woon Ki Paik
    Epsilon-alkyllysinase. Purification and properties of the enzyme (1964), J. Biol. Chem., 239, 3790-3796.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
phosphate stimulates enzyme in prepared mitochondrial fraction, but inhibits activity in crude homogenate Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
ascorbic acid moderate inhibition Rattus norvegicus
Co2+ strong inhibitory effect Rattus norvegicus
FAD moderate inhibition Rattus norvegicus
FMN moderate inhibition Rattus norvegicus
KCN 1.3 mM, about 40% inhibition Rattus norvegicus
Mn2+ moderate inhibition Rattus norvegicus
additional information not inhibited by semicarbazide Rattus norvegicus
NADH moderate inhibition Rattus norvegicus
Ni2+ strong inhibitory effect Rattus norvegicus
phosphate inhibits activity in crude homogenate, but stimulates enzyme in prepared mitochondrial fraction Rattus norvegicus
Zn2+ strong inhibitory effect Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.87
-
N6,N6-dimethyl-L-lysine
-
Rattus norvegicus
1.63
-
N6-methyl-L-lysine
-
Rattus norvegicus
5.95
-
N6-ethyl-L-lysine
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion 60% of the activity in rat kidney is present in the mitochondrial fraction Rattus norvegicus 5739
-
particle-bound
-
Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Cavia porcellus
-
-
-
Columba sp.
-
-
-
Felis catus
-
low activity
-
Gallus gallus
-
-
-
Mesocricetus auratus
-
-
-
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
2.78fold partial purification Rattus norvegicus
enzyme from kidney Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Cavia porcellus
-
kidney
-
Mus musculus
-
kidney
-
Canis lupus familiaris
-
kidney highest activity Rattus norvegicus
-
kidney higher activity than in liver Gallus gallus
-
kidney higher activity than in liver Rattus norvegicus
-
kidney higher activity than in liver Oryctolagus cuniculus
-
kidney higher activity than in liver Mesocricetus auratus
-
kidney higher activity than in liver Felis catus
-
kidney higher activity than in liver Columba sp.
-
liver
-
Mus musculus
-
liver
-
Canis lupus familiaris
-
liver low activity Gallus gallus
-
liver low activity Cavia porcellus
-
liver low activity Columba sp.
-
liver lower activity than in kidney Gallus gallus
-
liver lower activity than in kidney Rattus norvegicus
-
liver lower activity than in kidney Oryctolagus cuniculus
-
liver lower activity than in kidney Mesocricetus auratus
-
liver lower activity than in kidney Felis catus
-
liver lower activity than in kidney Columba sp.
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0044
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-(methylamino)-2-oxohexanoic acid + H2O + O2 15% of the activity with N6-methyl-L-lysine Rattus norvegicus 6-amino-2-oxohexanoic acid + formaldehyde + H2O2
-
?
6-(methylamino)-2-oxohexanoic acid + H2O + O2 free alpha-amino group is not required for susceptibility Rattus norvegicus 6-amino-2-oxohexanoic acid + formaldehyde + H2O2
-
?
additional information not: delta-N-monomethyl-L-ornithine Rattus norvegicus ?
-
?
additional information not: several acyl derivatives, alpha-N-methyl-L-lysine Rattus norvegicus ?
-
?
additional information activity restricted to epsilon-N-alkyllysine derivatives Rattus norvegicus ?
-
?
N6,N6-dimethyl-L-lysine + O2 + H2O 46% of the activity with N6-methyl-L-lysine, it may be oxidized by a different enzyme Rattus norvegicus L-lysine + formaldehyde + H2O2
-
?
N6,N6-dimethyl-L-lysine + O2 + H2O enzyme consumes per molecule N6,N6-dimethyl-L-lysine one molecule of oxygen Rattus norvegicus L-lysine + formaldehyde + H2O2
-
?
N6-ethyl-L-lysine + H2O + O2 about 50% of the activity with N6-methyl-L-lysine Rattus norvegicus L-lysine + acetaldehyde + H2O2
-
?
N6-methyl-D-lysine + H2O + O2 11% of the activity with epsilon-N-methyl-L-lysine Rattus norvegicus D-lysine + formaldehyde + H2O2
-
?
N6-methyl-L-lysine + O2 + H2O
-
Gallus gallus L-lysine + formaldehyde + H2O2
-
?
N6-methyl-L-lysine + O2 + H2O
-
Cavia porcellus L-lysine + formaldehyde + H2O2
-
?
N6-methyl-L-lysine + O2 + H2O
-
Mus musculus L-lysine + formaldehyde + H2O2
-
?
N6-methyl-L-lysine + O2 + H2O
-
Oryctolagus cuniculus L-lysine + formaldehyde + H2O2
-
?
N6-methyl-L-lysine + O2 + H2O
-
Canis lupus familiaris L-lysine + formaldehyde + H2O2
-
?
N6-methyl-L-lysine + O2 + H2O
-
Mesocricetus auratus L-lysine + formaldehyde + H2O2
-
?
N6-methyl-L-lysine + O2 + H2O
-
Felis catus L-lysine + formaldehyde + H2O2
-
?
N6-methyl-L-lysine + O2 + H2O
-
Columba sp. L-lysine + formaldehyde + H2O2
-
?
N6-methyl-L-lysine + O2 + H2O highest enzyme activity Rattus norvegicus L-lysine + formaldehyde + H2O2
-
?
N6-methyl-L-lysine + O2 + H2O enzyme consumes per mol N6-methyl-L-lysine half a mol of oxygen Rattus norvegicus L-lysine + formaldehyde + H2O2
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
38
-
assay at Rattus norvegicus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
additional information
-
enzyme is resistant to heat, far more stable in presence of substrates Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
partially purified enzyme Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6 7.8 pH 6: about 10% of activity maximum, pH 7.8: about 15% of activity maximum Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
FAD enzyme is most likely a flavoprotein Rattus norvegicus
additional information no cofactor requirement Rattus norvegicus