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Literature summary for 1.5.3.17 extracted from

  • Müller, S.; Hunter, K.J.; Walter, R.D.
    Effect of haloallylamines on polyamine oxidase activity and spermine levels in Ascaris suum (1996), Parasitol. Res., 82, 571-573.
    View publication on PubMed

Application

Application Comment Organism
medicine the inhibitor MDL 72145 might be a chemical lead compound for the design of new chemotherapeutic agents against nematode infections Ascaris suum

Inhibitors

Inhibitors Comment Organism Structure
MDL 72145 inhibited in a time-dependent manner. Half-life under saturation conditions is 0.8 min. MDL 72145 might be a chemical lead compound for the design of new chemotherapeutic agents against nematode infections Ascaris suum
MDL 72527 the specific inhibitor of mammalian polyamine oxidase, has no effect on the Ascaris suum enzyme Ascaris suum

Organism

Organism UniProt Comment Textmining
Ascaris suum
-
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0009
-
MDL 72145
-
Ascaris suum