Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.5.3.16 extracted from

  • Di Paolo, M.L.; Cervelli, M.; Mariottini, P.; Leonetti, A.; Polticelli, F.; Rosini, M.; Milelli, A.; Basagni, F.; Venerando, R.; Agostinelli, E.; Minarini, A.
    Exploring the activity of polyamine analogues on polyamine and spermine oxidase methoctramine, a potent and selective inhibitor of polyamine oxidase (2019), J. Enzyme Inhib. Med. Chem., 34, 740-752 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.5.3.16

Inhibitors

Inhibitors Comment Organism Structure
6,6'-[ethane-1,2-diyldi(piperidine-4,1-diyl)]bis[N-[(2-methoxyphenyl)methyl]hexan-1-amine] 17fold selectivity for spermine oxidase over polyamine oxidase Mus musculus
Chlorhexidine
-
 Mus musculus
methoctramine 120fold selectivity for spermine oxidase over polyamine oxidase Mus musculus
N1,N1'-(pentane-1,5-diyl)bis[N6-[(2-methoxyphenyl)methyl]hexane-1,6-diamine] 9fold selectivity for spermine oxidase over polyamine oxidase Mus musculus
N1,N7-bis(6-[[(2-methoxyphenyl)methyl]amino]hexyl)heptane-1,7-diamine 40fold selectivity for spermine oxidase over polyamine oxidase Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
 N1-[(thiophen-2-yl)methyl]spermine pH 7.5, 37°C Mus musculus
0.015
-
 N1-[(naphthalen-2-yl)methyl]spermine pH 7.5, 37°C Mus musculus
0.019
-
 N1-benzylspermine pH 7.5, 37°C Mus musculus
0.245
-
 N1-[(pyridin-2-yl)methyl]spermine pH 7.5, 37°C Mus musculus
0.495
-
 spermine pH 7.5, 37°C Mus musculus
1.06
-
 N1-(3-[[(thiophen-2-yl)methyl]amino]propyl)octane-1,8-diamine pH 7.5, 37°C Mus musculus
1.74
-
 N1-[(thiophen-2-yl)methyl]dodecane-1,12-diamine pH 7.5, 37°C Mus musculus
1.99
-
 N1-benzyldodecane-1,12-diamine pH 7.5, 37°C Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q99K82
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N1-(3-[[(thiophen-2-yl)methyl]amino]propyl)octane-1,8-diamine + O2 + H2O
-
 Mus musculus octane-1,8-diamine + N1-[(thiophen-2-yl)methyl]propanal + H2O2
-
 ?
N1-benzyldodecane-1,12-diamine + O2 + H2O
-
 Mus musculus dodecane-1,12-diamine + N1-benzylpropanal + H2O2
-
 ?
N1-benzylspermine + O2 + H2O
-
 Mus musculus spermidine + 3-(benzylamino)propanal + H2O2
-
 ?
N1-[(naphthalen-2-yl)methyl]spermine + O2 + H2O
-
 Mus musculus spermidine + N1-[(naphthalen-2-yl)methyl]propanal + H2O2
-
 ?
N1-[(pyridin-2-yl)methyl]spermine + O2 + H2O
-
 Mus musculus spermidine + N1-[(pyridin-2-yl)methyl]propanal + H2O2
-
 ?
N1-[(thiophen-2-yl)methyl]dodecane-1,12-diamine + O2 + H2O
-
 Mus musculus ?
-
 ?
N1-[(thiophen-2-yl)methyl]spermine + O2 + H2O
-
 Mus musculus spermidine + N1-[(thiophen-2-yl)methyl]propanal + H2O2
-
 ?
spermine + O2 + H2O
-
 Mus musculus spermidine + 3-aminopropanal + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
SMOX
-
 Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0012
-
 methoctramine pH 7.5, 37°C Mus musculus
0.0019
-
 N1,N7-bis(6-[[(2-methoxyphenyl)methyl]amino]hexyl)heptane-1,7-diamine pH 7.5, 37°C Mus musculus
0.0038
-
 Chlorhexidine pH 7.5, 37°C Mus musculus
0.0046
-
 N1,N1'-(pentane-1,5-diyl)bis[N6-[(2-methoxyphenyl)methyl]hexane-1,6-diamine] pH 7.5, 37°C Mus musculus
0.0075
-
 6,6'-[ethane-1,2-diyldi(piperidine-4,1-diyl)]bis[N-[(2-methoxyphenyl)methyl]hexan-1-amine] pH 7.5, 37°C Mus musculus