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Literature summary for 1.5.3.16 extracted from

  • Bonaiuto, E.; Grancara, S.; Martinis, P.; Stringaro, A.; Colone, M.; Agostinelli, E.; Macone, A.; Stevanato, R.; Vianello, F.; Toninello, A.; Di Paolo, M.L.
    A novel enzyme with spermine oxidase properties in bovine liver mitochondria identification and kinetic characterization (2015), Free Radic. Biol. Med., 81, 88-99 .
    View publication on PubMed
Search for more literature for 1.5.3.16

Inhibitors

Inhibitors Comment Organism Structure
N,N'-bis(2,3-butadienyl)-1,4-butanediamine i.e. MDL72527 Bos taurus
triethylenetetramine competitive inhibitor with spermine as substrate Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.211
-
 spermine pH 7.2, 37°C Bos taurus
1.898
-
 N,N'-bis(3-aminopropyl)ethylenediamine pH 7.2, 37°C Bos taurus
2.125
-
 N1-acetylspermine pH 7.2, 37°C Bos taurus
2.34
-
 spermidine pH 7.2, 37°C Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial matrix
-
 Bos taurus 5759
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N,N'-bis(3-aminopropyl)ethylenediamine + O2 + H2O
-
 Bos taurus ?
-
 ?
N1-acetylspermine + O2 + H2O
-
 Bos taurus ?
-
 ?
spermidine + O2 + H2O
-
 Bos taurus ?
-
 ?
spermine + O2 + H2O
-
 Bos taurus spermidine + 3-aminopropanal + H2O2
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.172
-
 triethylenetetramine pH 7.2, 37°C, with spermine as substrate Bos taurus