Literature summary for 1.5.3.16 extracted from

Cervelli, M.; Bellavia, G.; Fratini, E.; Amendola, R.; Polticelli, F.; Barba, M.; Federico, R.; Signore, F.; Gucciardo, G.; Grillo, R.; Woster, P.; Casero Jr, R.; Mariottini, P.
Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm (2010), BMC Cancer, 10, 555.

Search for more literature for 1.5.3.16

Application

Application	Comment	Organism
medicine	both the expression level of SMO mRNA and SMO enzyme activity are significantly lower in breast cancer samples compared to nontumor samples	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
-	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
bis(ethyl)norspermine	structure modeling analysis of complex formed with SMO	Homo sapiens
bis(ethyl)norspermine	-	Mus musculus
N,N' -bis(2,3-butadienyl)-1,4-butanediamine	i.e. MDL72527	Mus musculus
N1-ethyl-N11-(cyclopropyl)-methyl-4,8-diazaundecane	structure modeling analysis of complex formed with SMO	Homo sapiens
N1-ethyl-N11-(cyclopropyl)-methyl-4,8-diazaundecane	-	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	-	Homo sapiens	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.063	-	N,N' -bis(2,3-butadienyl)-1,4-butanediamine	pH 8.5, 25°C	Mus musculus
0.085	-	N1-ethyl-N11-(cyclopropyl)-methyl-4,8-diazaundecane	pH 8.5, 25°C	Mus musculus
0.38	-	bis(ethyl)norspermine	pH 8.5, 25°C	Mus musculus

Expression

Organism	Comment	Expression
Homo sapiens	both the expression level of SMO mRNA and SMO enzyme activity are significantly lower in breast cancer samples compared to nontumor samples	down

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)