Cloned (Comment) | Organism |
---|---|
cDNA is transiently transfected into HEK-293 cells | Mus musculus |
cDNA is transiently transfected into HEK-293 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
MDL-72527 | 0.2 mM, 41% inhibition | Homo sapiens | |
N1,N11-diethylnorspermine | 0.2 mM, 21% inhibition | Homo sapiens | |
N1,N12-diethylspermine | 0.2 mM, 15% inhibition | Homo sapiens | |
N1,N14-diethylhomospermine | 0.2 mM, 49% inhibition | Homo sapiens | |
N1-(n-octanesulfonyl)spermine | 0.2 mM, 86% inhibition | Homo sapiens | |
spermidine | 0.2 mM, 41% inhibition | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
spermine + O2 + H2O | Homo sapiens | SMO may contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-aminopropanal | spermidine + 3-aminopropanal + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NWM0 | - |
- |
Mus musculus | Q99K82 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | no activity with: spermidine, N1,N12-diacetylspermine, N1,N12-diethylspermine, N1,N14-diethylhomospermine, MDL-72527, N1,N11-diethylnorspermine | Homo sapiens | ? | - |
? | |
N1-acetylspermine + O2 + H2O | very poor substrate | Homo sapiens | ? | - |
? | |
N1-monoethylspermine + O2 + H2O | 98% of the activity with spermine | Homo sapiens | spermidine + ? | - |
? | |
spermine + O2 + H2O | - |
Homo sapiens | spermidine + 3-aminopropanal + H2O2 | - |
? | |
spermine + O2 + H2O | SMO may contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-aminopropanal | Homo sapiens | spermidine + 3-aminopropanal + H2O2 | - |
? | |
spermine + O2 + H2O | strongly favours spermine over N1-acetylspermine, fails to act on N1-acetylspermidine, spermidine or the preferred PAO substrate, N1,N12-diacetylspermine | Mus musculus | spermidine + 3-aminopropanal + H2O2 | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9.5 | - |
- |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Mus musculus | |
FAD | - |
Homo sapiens |