BRENDA - Enzyme Database
show all sequences of 1.5.3.16

Heterologous expression and biochemical characterization of a polyamine oxidase from Arabidopsis involved in polyamine back conversion

Tavladoraki, P.; Rossi, M.N.; Saccuti, G.; Perez-Amador, M.A.; Polticelli, F.; Angelini, R.; Federico, R.; Plant Physiol. 141, 1519-1532 (2006)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
AtPAO1 cDNA is isolated and cloned in a vector for heterologous expression in Escherichia coli
Arabidopsis thaliana
Inhibitors
Inhibitors
Commentary
Organism
Structure
1,12-diaminododecane
-
Arabidopsis thaliana
1,8-diaminooctane
-
Arabidopsis thaliana
agmatine
-
Arabidopsis thaliana
guazatine
-
Arabidopsis thaliana
MDL72527
-
Arabidopsis thaliana
N-prenylagmatine
-
Arabidopsis thaliana
spermidine
-
Arabidopsis thaliana
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.09
-
norspermine
pH 8.0
Arabidopsis thaliana
0.11
-
spermine
pH 8.0
Arabidopsis thaliana
0.47
-
N1-acetylspermine
pH 8.0
Arabidopsis thaliana
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Arabidopsis thaliana
no activity with spermidine
?
-
-
-
spermine + O2 + H2O
Arabidopsis thaliana
enzyme is involved in a polyamine back-conversion pathway
spermidine + 3-aminopropanal + H2O2
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Arabidopsis thaliana
Q9FNA2
-
-
Purification (Commentary)
Commentary
Organism
recombinant protein
Arabidopsis thaliana
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
no activity with spermidine
676604
Arabidopsis thaliana
?
-
-
-
-
N1-acetylspermine + O2 + H2O
-
676604
Arabidopsis thaliana
spermidine + 3-acetamidopropanal + H2O2
-
-
-
?
norspermine + O2 + H2O
-
676604
Arabidopsis thaliana
?
-
-
-
?
spermine + O2 + H2O
-
676604
Arabidopsis thaliana
spermidine + 3-aminopropanal + H2O2
-
-
-
?
spermine + O2 + H2O
enzyme is involved in a polyamine back-conversion pathway
676604
Arabidopsis thaliana
spermidine + 3-aminopropanal + H2O2
-
-
-
?
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.2
-
N1-acetylspermine
pH 8.0
Arabidopsis thaliana
2.7
-
spermine
pH 8.0
Arabidopsis thaliana
6.9
-
norspermine
pH 8.0
Arabidopsis thaliana
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
substrate: spermine or norspermine
Arabidopsis thaliana
pH Range
pH Minimum
pH Maximum
Commentary
Organism
7
9
pH 7: about 60% of maximal activity, pH 9.0: about 60% of maximal activity, substrate: spermine; pH 7: about 80% of maximal activity, pH 9.0: about 60% of maximal activity, substrate: norspermine
Arabidopsis thaliana
Cofactor
Cofactor
Commentary
Organism
Structure
FAD
all FAD molecules in the purified enzyme are catalytically active
Arabidopsis thaliana
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.0007
-
guazatine
pH 8.0, substrate: spermine
Arabidopsis thaliana
0.004
-
N-prenylagmatine
pH 8.0, substrate: spermine
Arabidopsis thaliana
0.0117
-
1,12-diaminododecane
pH 8.0, substrate: spermine
Arabidopsis thaliana
0.1373
-
MDL72527
pH 8.0, substrate: spermine
Arabidopsis thaliana
0.147
-
agmatine
pH 8.0, substrate: spermine
Arabidopsis thaliana
0.293
-
1,8-diaminooctane
pH 8.0, substrate: spermine
Arabidopsis thaliana
0.546
-
spermidine
pH 8.0, substrate: spermine
Arabidopsis thaliana
Cloned(Commentary) (protein specific)
Commentary
Organism
AtPAO1 cDNA is isolated and cloned in a vector for heterologous expression in Escherichia coli
Arabidopsis thaliana
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
FAD
all FAD molecules in the purified enzyme are catalytically active
Arabidopsis thaliana
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
1,12-diaminododecane
-
Arabidopsis thaliana
1,8-diaminooctane
-
Arabidopsis thaliana
agmatine
-
Arabidopsis thaliana
guazatine
-
Arabidopsis thaliana
MDL72527
-
Arabidopsis thaliana
N-prenylagmatine
-
Arabidopsis thaliana
spermidine
-
Arabidopsis thaliana
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.0007
-
guazatine
pH 8.0, substrate: spermine
Arabidopsis thaliana
0.004
-
N-prenylagmatine
pH 8.0, substrate: spermine
Arabidopsis thaliana
0.0117
-
1,12-diaminododecane
pH 8.0, substrate: spermine
Arabidopsis thaliana
0.1373
-
MDL72527
pH 8.0, substrate: spermine
Arabidopsis thaliana
0.147
-
agmatine
pH 8.0, substrate: spermine
Arabidopsis thaliana
0.293
-
1,8-diaminooctane
pH 8.0, substrate: spermine
Arabidopsis thaliana
0.546
-
spermidine
pH 8.0, substrate: spermine
Arabidopsis thaliana
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.09
-
norspermine
pH 8.0
Arabidopsis thaliana
0.11
-
spermine
pH 8.0
Arabidopsis thaliana
0.47
-
N1-acetylspermine
pH 8.0
Arabidopsis thaliana
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Arabidopsis thaliana
no activity with spermidine
?
-
-
-
spermine + O2 + H2O
Arabidopsis thaliana
enzyme is involved in a polyamine back-conversion pathway
spermidine + 3-aminopropanal + H2O2
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant protein
Arabidopsis thaliana
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
no activity with spermidine
676604
Arabidopsis thaliana
?
-
-
-
-
N1-acetylspermine + O2 + H2O
-
676604
Arabidopsis thaliana
spermidine + 3-acetamidopropanal + H2O2
-
-
-
?
norspermine + O2 + H2O
-
676604
Arabidopsis thaliana
?
-
-
-
?
spermine + O2 + H2O
-
676604
Arabidopsis thaliana
spermidine + 3-aminopropanal + H2O2
-
-
-
?
spermine + O2 + H2O
enzyme is involved in a polyamine back-conversion pathway
676604
Arabidopsis thaliana
spermidine + 3-aminopropanal + H2O2
-
-
-
?
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.2
-
N1-acetylspermine
pH 8.0
Arabidopsis thaliana
2.7
-
spermine
pH 8.0
Arabidopsis thaliana
6.9
-
norspermine
pH 8.0
Arabidopsis thaliana
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
substrate: spermine or norspermine
Arabidopsis thaliana
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
7
9
pH 7: about 60% of maximal activity, pH 9.0: about 60% of maximal activity, substrate: spermine; pH 7: about 80% of maximal activity, pH 9.0: about 60% of maximal activity, substrate: norspermine
Arabidopsis thaliana
Other publictions for EC 1.5.3.16
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
742553
Ceci
Adaptive responses of heart a ...
Mus musculus
Free Radic. Biol. Med.
103
216-225
2017
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
7
-
-
2
-
-
-
-
-
-
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-
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-
-
-
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-
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-
1
-
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7
-
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2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
741586
Cervelli
Stability of spermine oxidase ...
Mus musculus
Amino Acids
48
2283-2291
2016
-
-
1
-
1
-
-
2
-
-
-
-
-
3
-
-
1
-
-
1
-
2
1
2
-
-
2
2
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
2
-
-
-
-
-
-
-
1
-
1
-
2
1
2
-
-
2
2
-
-
-
-
-
-
-
-
2
2
742600
Tavladoraki
Copper-containing amine oxida ...
Arabidopsis thaliana
Front. Plant Sci.
7
824
2016
-
-
-
-
-
-
-
-
1
-
-
1
-
2
-
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4
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1
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1
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4
-
-
-
-
-
-
-
-
-
-
1
2
-
-
-
741571
Bongers
Spermine oxidase maintains ba ...
Mus musculus
Am. J. Physiol. Endocrinol. Metab.
308
E144-E158
2015
-
1
-
-
-
-
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2
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1
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1
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1
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1
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-
-
-
-
-
-
-
2
2
-
-
-
742522
Sagor
The polyamine oxidase from ly ...
Selaginella lepidophylla
FEBS Lett.
589
3071-3078
2015
-
-
1
-
-
-
-
-
-
-
-
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-
1
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1
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1
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1
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1
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1
-
1
-
-
-
1
-
-
-
2
-
-
2
-
-
742563
Bonaiuto
A novel enzyme with spermine ...
Bos taurus
Free Radic. Biol. Med.
81
88-99
2015
-
-
-
-
-
-
2
4
2
-
-
-
-
3
-
-
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-
-
2
-
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4
-
1
-
-
-
1
-
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-
1
-
-
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-
-
-
-
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-
2
1
4
2
-
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-
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-
-
-
-
2
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
743472
Mo
Cotton polyamine oxidase is r ...
Gossypium hirsutum
Plant J.
83
962-975
2015
-
-
1
-
-
-
-
-
-
-
-
1
-
7
-
-
-
-
-
-
-
-
2
1
1
1
-
-
1
1
-
-
-
-
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-
1
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-
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-
-
-
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-
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-
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1
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-
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-
-
-
-
-
2
1
1
1
-
-
1
1
-
-
-
1
1
-
-
-
741582
Chaturvedi
Spermine oxidase is a regulat ...
Homo sapiens, Mus musculus
Amino Acids
46
531-542
2014
-
-
-
-
-
-
-
-
-
-
-
2
-
6
-
-
-
-
-
3
-
-
4
-
-
-
-
-
-
-
-
-
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-
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-
2
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3
-
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4
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
741851
Cervelli
The Glu216/Ser218 pocket is a ...
Mus musculus
Biochem. J.
461
453-459
2014
-
-
-
-
1
-
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-
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-
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2
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2
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2
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-
742034
Moriya
Development of irreversible i ...
Homo sapiens
Biol. Pharm. Bull.
37
475-480
2014
-
-
1
-
-
-
2
-
-
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-
1
-
2
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2
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1
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1
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1
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2
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1
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2
-
1
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1
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1
1
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742993
Ahou
A plant spermine oxidase/dehy ...
Arabidopsis thaliana
J. Exp. Bot.
65
1585-1603
2014
-
-
-
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-
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-
3
1
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1
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1
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5
-
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1
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1
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1
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3
1
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1
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5
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1
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1
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1
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743491
Kim
Polyamine oxidase 5 regulates ...
Arabidopsis thaliana
Plant Physiol.
165
1575-1590
2014
-
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2
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1
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3
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2
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1
1
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1
1
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1
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2
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2
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1
1
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2
1
1
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2
2
-
2
2
724499
Takao
Pentamines as substrate for hu ...
Homo sapiens
Biol. Pharm. Bull.
36
407-411
2013
-
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1
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1
1
2
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1
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3
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5
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1
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1
1
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1
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1
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1
2
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1
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5
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1
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1
1
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725069
Capone
A role for spermine oxidase as ...
Homo sapiens
Free Radic. Biol. Med.
63
99-107
2013
1
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1
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3
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3
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1
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1
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1
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3
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1
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1
1
1
1
-
-
725753
Cervelli
in the evolutionary framework ...
Homo sapiens, Mus musculus, vertebrata
J. Mol. Evol.
76
365-370
2013
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3
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2
4
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3
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4
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2
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8
-
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2
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3
-
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3
3
-
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2
4
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3
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2
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8
-
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-
2
-
-
-
-
-
4
4
-
2
2
742985
Cervelli
-
Inhibition of acetylpolyamine ...
Mus musculus
J. Enzyme Inhib. Med. Chem.
28
463-467
2013
-
1
1
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2
1
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1
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1
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2
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1
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1
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1
1
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2
1
1
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1
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2
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1
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1
1
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743048
Hou
-
Regulatory function of polyam ...
Arabidopsis thaliana
J. Integr. Agric.
12
251-262
2013
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1
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1
1
-
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-
723918
Cervelli
Spermine oxidase: ten years af ...
Homo sapiens, Mus musculus
Amino Acids
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Fincato
The members of Arabidopsis tha ...
Arabidopsis thaliana
Amino Acids
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2012
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Moriya
A mass spectrometric method to ...
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Anal. Chim. Acta
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2012
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Tavladoraki
Probing mammalian spermine oxi ...
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Amino Acids
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Fincato
Functional diversity inside th ...
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Mechanistic studies of human s ...
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Cervelli
Spermine oxidase (SMO) activit ...
Homo sapiens, Mus musculus
BMC Cancer
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712194
Fiori
Genetic and epigenetic influen ...
Homo sapiens
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Fincato
Functional diversity inside th ...
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Characterization of five polya ...
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Metabolism of N-alkylated sper ...
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Increased expression and cellu ...
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The polyamine analogue N1,N11- ...
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Tumor necrosis factor-alpha in ...
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Direct oxidative DNA damage, a ...
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Bianchi
Two short protein domains are ...
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Cervelli
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