Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.5.1.9 extracted from

  • Wan, P.; Yuan, S.; Tang, Y.; Li, K.; Yang, L.; Fu, Q.; Li, G.
    Pathways of amino acid degradation in Nilaparvata lugens (Stal) with special reference to lysine-ketoglutarate reductase/saccharopine dehydrogenase (LKR/SDH) (2015), PLoS ONE, 10, e0127789 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.5.1.9

Cloned(Commentary)

Cloned (Comment) Organism
gene nllkr/sdh, DNA and amino acid sequence determination and analysis, phylogenic analysis, quantitative real-time PCR expression analysis Nilaparvata lugens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Nilaparvata lugens
-
 L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Nilaparvata lugens A0A089MUZ6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adult
-
 Nilaparvata lugens
-
egg
-
 Nilaparvata lugens
-
additional information Nilaparvata lugens are maintained on rice variety Taichung Native 1 (TN1) for more than 170 generations under controlled conditions. Temporal transcript profile of Nllkr/sdh in nymphs and adults, quantitative real-time PCR expression analysis. Nllkr/sdh is widely expressed in the eggs, first- through fifth-instar nymphs, and adults. The expression levels varies little among different development stages Nilaparvata lugens
-
nymph
-
 Nilaparvata lugens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is bifunctional catalyzing the reaction of EC 1.5.1.8, saccharopine dehydrogenase (NADP+, L-lysine-forming) in the reverse direction, and EC 1.5.1.9, saccharopine dehydrogenase (NAD+, L-glutamate-forming) Nilaparvata lugens ?
-
 ?
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 Nilaparvata lugens L-glutamate + (S)-2-amino-6-oxohexanoate + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
LKR/SDH
-
 Nilaparvata lugens
lysine ketoglutarate/reductase saccharopine dehydrogenase
-
 Nilaparvata lugens
nllkr/sdh
-
 Nilaparvata lugens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Nilaparvata lugens

General Information

General Information Comment Organism
metabolism the enzyme is involved in L-lysine breakdown. In Nilaparvata lugens, the degradation of L-lysine is independent from the yeast-like endosymbionts of the organism, in contrast to degradation of other amino acids, overview Nilaparvata lugens