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Literature summary for 1.5.1.9 extracted from

  • Markovitz, P.J.; Chuang, D.T.; Cox, R.P.
    Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities (1984), J. Biol. Chem., 259, 11643-11646.
    View publication on PubMed
Search for more literature for 1.5.1.9

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Bos taurus 5739
-
mitochondrion
-
 Papio hamadryas 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
115000
-
 4 * 115000, SDS-PAGE, lysine-ketoglutarate reductase (EC 1. 5.1.8) and saccharopine dehydrogenase activity (EC 1.5.1.9) occur on a single protein, called aminoadipic semialdehyde synthase Bos taurus
115000
-
 4 * 115000, SDS-PAGE, lysine-ketoglutarate reductase (EC 1. 5.1.8) and saccharopine dehydrogenase activity (EC 1.5.1.9) occur on a single protein, called aminoadipic semialdehyde synthase Papio hamadryas
467000
-
 gel filtration, lysine-ketoglutarate reductase (EC 1. 5.1.8) and saccharopine dehydrogenase activity (EC 1.5.1.9) occur on a single protein, called aminoadipic semialdehyde synthase Papio hamadryas
468000
-
 gel filtration, lysine-ketoglutarate reductase (EC 1. 5.1.8) and saccharopine dehydrogenase activity (EC 1.5.1.9) occur on a single protein, called aminoadipic semialdehyde synthase Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Bos taurus involved in lysine catabolism L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Papio hamadryas involved in lysine catabolism L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 lysine-ketoglutarate reductase (EC 1. 5.1.8) and saccharopine dehydrogenase activity (EC 1.5.1.9) occur on a single protein, called aminoadipic semialdehyde synthase
-
Papio hamadryas
-
 baboon, lysine-ketoglutarate reductase (EC 1.5.1.8) and saccharopine dehydrogenase activity (EC 1.5.1.9) occur on a single protein, called aminoadipic semialdehyde synthase
-

Purification (Commentary)

Purification (Comment) Organism
lysine-ketoglutarate reductase (EC 1. 5.1.8) and saccharopine dehydrogenase activity (EC 1.5.1.9) occur on a single protein, called aminoadipic semialdehyde synthase Bos taurus
lysine-ketoglutarate reductase (EC 1. 5.1.8) and saccharopine dehydrogenase activity (EC 1.5.1.9) occur on a single protein, called aminoadipic semialdehyde synthase Papio hamadryas

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Bos taurus
-
liver
-
 Papio hamadryas
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.03
-
 crude extract Papio hamadryas
17.2
-
 after purification Papio hamadryas

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 Bos taurus L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 Papio hamadryas L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O involved in lysine catabolism Bos taurus L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O involved in lysine catabolism Papio hamadryas L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r

Subunits

Subunits Comment Organism
tetramer 4 * 115000, SDS-PAGE, lysine-ketoglutarate reductase (EC 1. 5.1.8) and saccharopine dehydrogenase activity (EC 1.5.1.9) occur on a single protein, called aminoadipic semialdehyde synthase Bos taurus
tetramer 4 * 115000, SDS-PAGE, lysine-ketoglutarate reductase (EC 1. 5.1.8) and saccharopine dehydrogenase activity (EC 1.5.1.9) occur on a single protein, called aminoadipic semialdehyde synthase Papio hamadryas

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Bos taurus
NAD+
-
 Papio hamadryas