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Literature summary for 1.5.1.8 extracted from

  • Fellows, F.C.I.; Lewis, M.H.R.
    Lysine metabolism in mammals (1973), Biochem. J., 136, 329-334.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.5.1.8

Application

Application Comment Organism
medicine hyperlysinemia: genetic disease, deficiency of lysine-ketoglutarate reductase results in extreme elevations of serum lysine Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-
mitochondrion
-
 Rattus norvegicus 5739
-
mitochondrion
-
 Sus scrofa 5739
-
mitochondrion
-
 Bos taurus 5739
-
mitochondrion
-
 Ovis aries 5739
-
mitochondrion
-
 Canis lupus familiaris 5739
-
mitochondrion
-
 Felis catus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-lysine + 2-oxoglutarate + NADPH Homo sapiens lysine catabolism N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
L-lysine + 2-oxoglutarate + NADPH Rattus norvegicus lysine catabolism N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
L-lysine + 2-oxoglutarate + NADPH Sus scrofa lysine catabolism N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
L-lysine + 2-oxoglutarate + NADPH Bos taurus lysine catabolism N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
L-lysine + 2-oxoglutarate + NADPH Ovis aries lysine catabolism N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
L-lysine + 2-oxoglutarate + NADPH Canis lupus familiaris lysine catabolism N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
L-lysine + 2-oxoglutarate + NADPH Felis catus lysine catabolism N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
L-lysine + 2-oxoglutarate + NADPH Homo sapiens important role in the degradation of lysine N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
L-lysine + 2-oxoglutarate + NADPH Rattus norvegicus Wistar lysine catabolism N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Canis lupus familiaris
-
 mongrels
-
Felis catus
-
 tabby
-
Homo sapiens
-
-
-
Ovis aries
-
-
-
Rattus norvegicus
-
 Wistar strain
-
Rattus norvegicus Wistar
-
 Wistar strain
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-
liver
-
 Sus scrofa
-
liver
-
 Bos taurus
-
liver
-
 Ovis aries
-
liver
-
 Canis lupus familiaris
-
liver
-
 Felis catus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens
additional information
-
-
 Rattus norvegicus
additional information
-
-
 Sus scrofa
additional information
-
-
 Bos taurus
additional information
-
-
 Ovis aries
additional information
-
-
 Canis lupus familiaris
additional information
-
-
 Felis catus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-lysine + 2-oxoglutarate + NADPH enzyme catalyzes lysine degradation to saccharopine Homo sapiens N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine ?
L-lysine + 2-oxoglutarate + NADPH enzyme catalyzes lysine degradation to saccharopine Rattus norvegicus N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine ?
L-lysine + 2-oxoglutarate + NADPH enzyme catalyzes lysine degradation to saccharopine Sus scrofa N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine ?
L-lysine + 2-oxoglutarate + NADPH enzyme catalyzes lysine degradation to saccharopine Bos taurus N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine ?
L-lysine + 2-oxoglutarate + NADPH enzyme catalyzes lysine degradation to saccharopine Ovis aries N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine ?
L-lysine + 2-oxoglutarate + NADPH enzyme catalyzes lysine degradation to saccharopine Canis lupus familiaris N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine ?
L-lysine + 2-oxoglutarate + NADPH enzyme catalyzes lysine degradation to saccharopine Felis catus N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine ?
L-lysine + 2-oxoglutarate + NADPH lysine catabolism Homo sapiens N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
L-lysine + 2-oxoglutarate + NADPH lysine catabolism Rattus norvegicus N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
L-lysine + 2-oxoglutarate + NADPH lysine catabolism Sus scrofa N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
L-lysine + 2-oxoglutarate + NADPH lysine catabolism Bos taurus N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
L-lysine + 2-oxoglutarate + NADPH lysine catabolism Ovis aries N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
L-lysine + 2-oxoglutarate + NADPH lysine catabolism Canis lupus familiaris N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
L-lysine + 2-oxoglutarate + NADPH lysine catabolism Felis catus N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
L-lysine + 2-oxoglutarate + NADPH important role in the degradation of lysine Homo sapiens N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
L-lysine + 2-oxoglutarate + NADPH enzyme catalyzes lysine degradation to saccharopine Rattus norvegicus Wistar N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine ?
L-lysine + 2-oxoglutarate + NADPH lysine catabolism Rattus norvegicus Wistar N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens
NADPH
-
 Rattus norvegicus
NADPH
-
 Sus scrofa
NADPH
-
 Bos taurus
NADPH
-
 Ovis aries
NADPH
-
 Canis lupus familiaris
NADPH
-
 Felis catus