Application | Comment | Organism |
---|---|---|
medicine | enzyme-induced suppressor effects are strictly dependent on p53 tumor suppressor protein in A549 cells. Enzyme elevation results in p53 phosphorylation at S6 and S20 in the p53 transactivation domain, and S392 in the C-terminal domain, but only S6 is strictly required to mediate enzyme effects | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | activation of p53 tumor suppressor protein-dependent pathways is a general downstream mechanism in response to induction of enzyme expression in p53 functional cancer cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | activation of p53 tumor suppressor protein-dependent pathways is a general downstream mechanism in response to induction of enzyme expression in p53 functional cancer cells | Homo sapiens | ? | - |
? |