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Literature summary for 1.5.1.6 extracted from
- Partial purification of a 10-formyl-tetrahydrofolate: NADP oxidoreductase from mammalian liver (1968), Biochem. Biophys. Res. Commun., 30, 111-117.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| tetrahydrofolate | - |
Sus scrofa |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 200fold partial purification | Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.305 | - |
- |
Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 10-formyltetrahydrofolate + NADP+ + H2O | specific for NADP+ | Sus scrofa | tetrahydrofolate + CO2 + NADPH + H+ | - |
? | |
| additional information | not as substrate: 5-formyltetrahydrofolate | Sus scrofa | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8.5 | in Tris buffer 30% faster reaction than in phosphate buffer | Sus scrofa |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| 10-formyltetrahydrofolate | 10-formyltetrahydrofolate | Sus scrofa | |
| additional information | no effect: NADPH | Sus scrofa | |
| NAD+ | less than 5% of the activity with NADP+ | Sus scrofa | |
| NADP+ | specific for | Sus scrofa | |
| tetrahydrofolate | - |
Sus scrofa | |
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