Literature summary for 1.5.1.53 extracted from

Vanoni, M.A.; Matthews, R.G.
Kinetic isotope effects on the oxidation of reduced nicotinamide adenine dinucleotide phosphate by the flavoprotein methylenetetrahydrofolate reductase (1984), Biochemistry, 23, 5272-5279 .

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Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Sus scrofa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5,10-methylenetetrahydrofolate + NADPH + H+	-	Sus scrofa	5-methyltetrahydrofolate + NADP+	-	?
5-methyltetrahydrofolate + oxidized menadione	-	Sus scrofa	5,10-methylenetetrahydrofolate + reduced menadione	-	?
NADPH + H+ + oxidized menadione	-	Sus scrofa	NADP+ + reduced menadione	-	?

General Information

General Information	Comment	Organism
metabolism	methylenetetrahydrofolate reductase stereospecifically removes the pro-S hydrogen from the 4-position of NADPH. The oxidation of NADPH is largely or entirely rate limiting in the reductive half-reaction and in NADPH-menadione oxidoreductase turnover at saturating menadione concentration	Sus scrofa

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Release 2023.1 (January 2023)