Literature summary for 1.5.1.5 extracted from

Bolusani, S.; Young, B.A.; Cole, N.A.; Tibbetts, A.S.; Momb, J.; Bryant, J.D.; Solmonson, A.; Appling, D.R.
Mammalian MTHFD2L encodes a mitochondrial methylenetetrahydrofolate dehydrogenase isozyme expressed in adult tissues (2011), J. Biol. Chem., 286, 5166-5174.

Search for more literature for 1.5.1.5

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Saccharomyces cerevisiae strain MWY4.4 and in CHO cells	Homo sapiens
expressed in Saccharomyces cerevisiae strain MWY4.4 and in CHO cells	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	the enzyme behaves as a tightly associated peripheral membrane protein of the mitochondrial inner membrane	Homo sapiens	5739	-
mitochondrion	the enzyme behaves as a tightly associated peripheral membrane protein of the mitochondrial inner membrane	Rattus norvegicus	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5,10-methylenetetrahydrofolate + NADP+	Homo sapiens	-	5,10-methenyltetrahydrofolate + NADPH + H+	-	?
5,10-methylenetetrahydrofolate + NADP+	Rattus norvegicus	-	5,10-methenyltetrahydrofolate + NADPH + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-
brain	-	Rattus norvegicus	-
heart	-	Rattus norvegicus	-
kidney	-	Rattus norvegicus	-
liver	-	Rattus norvegicus	-
lung	-	Rattus norvegicus	-
additional information	the enzyme is expressed in adult tissues	Homo sapiens	-
additional information	the enzyme is expressed in adult tissues	Rattus norvegicus	-
placenta	-	Homo sapiens	-
placenta	-	Rattus norvegicus	-
spleen	-	Rattus norvegicus	-
testis	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5,10-methylenetetrahydrofolate + NADP+	-	Homo sapiens	5,10-methenyltetrahydrofolate + NADPH + H+	-	?
5,10-methylenetetrahydrofolate + NADP+	-	Rattus norvegicus	5,10-methenyltetrahydrofolate + NADPH + H+	-	?

Synonyms

Synonyms	Comment	Organism
methylenetetrahydrofolate dehydrogenase	-	Homo sapiens
methylenetetrahydrofolate dehydrogenase	-	Rattus norvegicus
MTHFD2L	-	Homo sapiens
MTHFD2L	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	dependent on	Homo sapiens
NADP+	dependent on	Rattus norvegicus

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Release 2023.1 (January 2023)