Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Saccharomyces cerevisiae | |
Mg2+ | - |
Saccharomyces cerevisiae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.011 | - |
NADP+ | - |
Ovis aries | |
0.018 | - |
NADP+ | - |
Sus scrofa | |
0.022 | - |
5,10-methylenetetrahydrofolate | - |
Sus scrofa | |
0.038 | - |
5,10-methylenetetrahydrofolate | - |
Saccharomyces cerevisiae | |
0.039 | - |
5,10-methylenetetrahydrofolate | - |
Ovis aries | |
0.11 | - |
NADP+ | - |
Saccharomyces cerevisiae |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | and other monovalent metal cations | Saccharomyces cerevisiae |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
100000 | - |
2 * 100000, SDS-PAGE | Ovis aries |
150000 | - |
methylenetetrahydrofolate dehydrogenase, formyltetrahydrofolate synthetase and methenyltetrahydrofolate cyclohydrolase combined, gel filtration | Sus scrofa |
201000 | - |
methylenetetrahydrofolate dehydrogenase, formyltetrahydrofolate synthetase and methenyltetrahydrofolate cyclohydrolase combined, gel filtration | Saccharomyces cerevisiae |
226000 | - |
methylenetetrahydrofolate dehydrogenase, formyltetrahydrofolate synthetase and methenyltetrahydrofolate cyclohydrolase combined, gel filtration | Ovis aries |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + NADP+ | Sus scrofa | - |
5,10-methenyltetrahydrofolate + NADPH + H+ | - |
? | |
5,10-methylenetetrahydrofolate + NADP+ | Saccharomyces cerevisiae | - |
5,10-methenyltetrahydrofolate + NADPH + H+ | - |
? | |
5,10-methylenetetrahydrofolate + NADP+ | Ovis aries | - |
5,10-methenyltetrahydrofolate + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ovis aries | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
formyltetrahydrofolate synthetase, methenyltetrahydrofolate cyclohydrolase and methylenetetrahydrofolate dehydrogenase combined | Saccharomyces cerevisiae |
trifunctional enzyme: methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrase, formyltetrahydrofolate synthetase | Sus scrofa |
trifunctional enzyme: methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrase, formyltetrahydrofolate synthetase | Ovis aries |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Sus scrofa | - |
liver | - |
Ovis aries | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Ovis aries |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + NADP+ | - |
Sus scrofa | 5,10-methenyltetrahydrofolate + NADPH + H+ | - |
? | |
5,10-methylenetetrahydrofolate + NADP+ | - |
Saccharomyces cerevisiae | 5,10-methenyltetrahydrofolate + NADPH + H+ | - |
? | |
5,10-methylenetetrahydrofolate + NADP+ | - |
Ovis aries | 5,10-methenyltetrahydrofolate + NADPH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 100000, SDS-PAGE | Ovis aries |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Sus scrofa | |
NADP+ | - |
Saccharomyces cerevisiae | |
NADP+ | - |
Ovis aries |