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Literature summary for 1.5.1.40 extracted from

  • Hossain, M.S.; Le, C.Q.; Joseph, E.; Nguyen, T.Q.; Johnson-Winters, K.; Foss, F.W.
    Convenient synthesis of deazaflavin cofactor FO and its activity in F420-dependent NADP reductase (2015), Org. Biomol. Chem., 13, 5082-5085 .
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information analysis of the F420 redox moiety (FO)-dependent NADP+/NADPH redox process by stopped-flow spectrophotometry, steady state kinetics, overview Archaea

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
reduced coenzyme F420 + NADP+ Archaea
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oxidized coenzyme F420 + NADPH + H+
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r

Organism

Organism UniProt Comment Textmining
Archaea
-
methanogenic
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information F420 and the F420 redox moiety, FO, are phenolic 5-deazaflavin cofactors that complement nicotinamide and flavin redox coenzymes in biochemical oxidoreductases and photocatalytic systems. Specifically, these 5-deazaflavins lack the single electron reactivity with O2 of riboflavin-derived coenzymes (FMN and FAD), and, in general, have a more negative redox potential than NAD(P)+. A convenient synthesis of FO is achieved by improving the redox stability of synthetic intermediates containing a polar, electron-rich aminophenol fragment, Fno enzyme activity is restored with FO in the absence of F420, method optimization, overview Archaea ?
-
?
reduced coenzyme F420 + NADP+
-
Archaea oxidized coenzyme F420 + NADPH + H+
-
r

Synonyms

Synonyms Comment Organism
F420-dependent NADP+ oxidoreductase
-
Archaea
Fno
-
Archaea

General Information

General Information Comment Organism
physiological function F420-dependent NADP+ oxidoreductase (Fno) is critical to the conversion of CO2 to CH4 by methanogenic archaea, while the F420 redox moiety, FO, functions as a light-harvesting agent in DNA repair Archaea