Cloned (Comment) | Organism |
---|---|
expressed in HEK-293T cells | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
renal cortex | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
QDPR | - |
Rattus norvegicus |
quinoid dihydropteridine reductase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | enzyme expression is significantly decreased in the renal cortex of diabetic rats | down |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inhibition results in a significant increase in transforming growth factor-beta1 expression | Rattus norvegicus |
physiological function | the enzyme is an important factor mediating diabetic nephropathy through its regulation of transforming growth factor-beta1/Smad3 signaling and NADPH oxidase | Rattus norvegicus |