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Literature summary for 1.5.1.34 extracted from
- Dihydropteridine reductase activity in the brainstem of intrauterine growth-restricted rats (2010), Int. J. Dev. Neurosci., 28, 621-624.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-amino-4-hydroxy-6-methyl-5,6,7,8-tetrahydropteridine + NADH | - |
Rattus norvegicus | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dihydropteridine reductase | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | - |
assay at | Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | the brain stem of intrauterine growth-restricted offspring show significant increase of L-tryptophan, 5-hydroxytryptamine, tryptophan-5-hydroxylase and also dihydropteridine activity in the brain stem in comparison to controls. Intrauterine growth restriction produces an increase of serotonin biosynthesis in the brain stem. This is accompanied by an increase in dihydropteridine activity that appears to be a compensatory mechanism to maintain sufficient tetrahydrobiopterin for the donation of electrons during the accelerated synthesis of brain serotonin in intrauterine growth-restricted rats | Rattus norvegicus |
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Release 2023.1 (January 2023)
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