Literature summary for 1.5.1.34 extracted from

Shen, R.S.; Smith, R.V.; Davis, P.J.; Abell, C.W.
Inhibition of dihydropteridine reductase from human liver and rat striatal synaptosomes by apomorphine and its analogs (1984), J. Biol. Chem., 259, 8994-9000.

Inhibitors

Inhibitors	Comment	Organism
(R)-2,10,11-trihydroxy-N-n-propylaporphine	0.0017 mM, 50% inhibition	Homo sapiens
(R)-2,10,11-trihydroxy-N-n-propylaporphine	0.0016 mM, 50% inhibition	Rattus norvegicus
(R)-2,10,11-trihydroxyaporphine	0.0016 mM, 50% inhibition	Homo sapiens
(R)-2,10,11-trihydroxyaporphine	0.0007 mM, 50% inhibition	Rattus norvegicus
(R)-2,11-dihydroxy-10-methoxy-aporphine	0.013 mM, 50% inhibition	Homo sapiens
(R)-2,11-dihydroxy-10-methoxy-aporphine	0.016 mM, 50% inhibition	Rattus norvegicus
(R)-apocodeine	0.079 mM, 50% inhibition	Homo sapiens
(R)-apocodeine	0.087 mM, 50% inhibition	Rattus norvegicus
(R)-apomorphine	0.002 mM, 50% inhibition	Homo sapiens
(R)-apomorphine	0.0012 mM, 50% inhibition	Rattus norvegicus
(R)-N-chloroethylnorapomorphine	0.0029 mM, 50% inhibition	Homo sapiens
(R)-N-chloroethylnorapomorphine	0.0029 mM, 50% inhibition	Rattus norvegicus
(R)-N-hydroxyethylnorapomorphine	0.001 mM, 50% inhibition	Homo sapiens
(R)-N-hydroxyethylnorapomorphine	0.0013 mM, 50% inhibition	Rattus norvegicus
(R)-N-n-propylaporphine	-	Homo sapiens
(R)-N-n-propylaporphine	-	Rattus norvegicus
(R)-N-n-propylnorapomorphine	0.0018 mM, 50% inhibition	Homo sapiens
(R)-N-n-propylnorapomorphine	0.0017 mM, 50% inhibition	Rattus norvegicus
(R)-norapomorphine	0.0028 mM, 50% inhibition	Homo sapiens
(R)-norapomorphine	0.0014 mM, 50% inhibition	Rattus norvegicus
(S)-2,10,11-trihydroxyaporphine	0.0015 mM, 50% inhibition	Homo sapiens
(S)-2,10,11-trihydroxyaporphine	0.0014 mM, 50% inhibition	Rattus norvegicus
(S)-bulbocapnine	0.148 mM, 50% inhibition	Homo sapiens
(S)-bulbocapnine	0.151 mM, 50% inhibition	Rattus norvegicus
(S)-N-n-propylnorapomorphine	0.0022 mM, 50% inhibition	Homo sapiens
(S)-N-n-propylnorapomorphine	0.0018 mM, 50% inhibition	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
synaptosome	striatum	Rattus norvegicus	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-
liver	-	Rattus norvegicus	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism
0.0012	-	(R)-apomorphine	-	Rattus norvegicus
0.0013	-	(R)-N-n-propylaporphine	-	Rattus norvegicus
0.0019	-	(R)-2,10,11-trihydroxyapomorphine	-	Homo sapiens
0.0019	-	(R)-2,10,11-trihydroxyapomorphine	-	Rattus norvegicus
0.0022	-	(R)-apomorphine	-	Homo sapiens
0.0022	-	(R)-N-n-propylaporphine	-	Homo sapiens