Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,4-diamino-6-bromo-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Trypanosoma brucei | |
2,4-diamino-6-[(E)-2-phenylethenyl]-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile | - |
Trypanosoma brucei | |
2,4-diamino-6-[(Z)-2-(4-methylphenyl)ethenyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Trypanosoma brucei | |
2,4-diamino-6-[(Z)-2-phenylethenyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Trypanosoma brucei | |
2,4-diamino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Trypanosoma brucei | |
2-amino-4-(1-pyrrolidinyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Trypanosoma brucei | |
2-amino-4-(cyclopentyloxy)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Trypanosoma brucei | |
2-amino-4-(thiomorpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Trypanosoma brucei | |
2-amino-4-methoxy-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Trypanosoma brucei | |
2-amino-4-oxo-6-[(E)-2-phenylethenyl]-4,7-dihydro-3Hpyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Trypanosoma brucei | |
2-amino-4-[(propan-2-yl)oxy]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Trypanosoma brucei | |
2-amino-5,6-bis(4-chlorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | - |
Trypanosoma brucei | |
2-amino-5,6-bis(4-fluorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | - |
Trypanosoma brucei | |
2-amino-5,6-bis(4-methylphenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | - |
Trypanosoma brucei | |
2-amino-5,6-diphenyl-3,7-dihydro-4H-pyrrolo[2,3-d]-pyrimidin-4-one | - |
Trypanosoma brucei | |
2-amino-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | - |
Trypanosoma brucei | |
2-amino-5-(3-chlorophenyl)-6-(4-fluorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | - |
Trypanosoma brucei | |
2-amino-5-(4-fluorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | - |
Trypanosoma brucei | |
2-amino-5-(4-methylphenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | - |
Trypanosoma brucei | |
2-amino-5-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | - |
Trypanosoma brucei | |
2-amino-5-methyl-6-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | - |
Trypanosoma brucei | |
2-amino-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | - |
Trypanosoma brucei | |
2-amino-6-(3-formylphenyl)-4-(1-pyrrolidinyl)-7H-pyrrolo-[2,3-d]pyrimidine-5-carbonitrile | - |
Trypanosoma brucei | |
2-amino-6-(4-bromophenyl)-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | - |
Trypanosoma brucei | |
2-amino-6-(4-fluorophenyl)-5-(4-methoxyphenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | - |
Trypanosoma brucei | |
2-amino-6-(4-fluorophenyl)-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | - |
Trypanosoma brucei | |
2-amino-6-bromo-4-(1-pyrrolidinyl)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile | - |
Trypanosoma brucei | |
2-amino-6-phenyl-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | - |
Trypanosoma brucei | |
2-amino-6-[3-(methanesulfonyl)phenyl]-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | - |
Trypanosoma brucei | |
2-amino-6-[4-(2-methylpropyl)phenyl]-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | - |
Trypanosoma brucei | |
2-amino-6-[4-(methanesulfonyl)phenyl]-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | - |
Trypanosoma brucei | |
2-amino-6-[4-[3-(4-morpholinyl)propyl]phenyl]-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one trifluoroacetate | - |
Trypanosoma brucei | |
4-(1-pyrrolidinyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine | - |
Trypanosoma brucei | |
4-(thiomorpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine | - |
Trypanosoma brucei | |
5,6-bis(4-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | - |
Trypanosoma brucei | |
5,6-bis(4-chlorophenyl)-N~4~,N~4~-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | - |
Trypanosoma brucei | |
5,6-bis(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | - |
Trypanosoma brucei | |
5,6-bis(4-fluorophenyl)-N~4~,N~4~-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | - |
Trypanosoma brucei | |
5,6-bis(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | - |
Trypanosoma brucei | |
5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | - |
Trypanosoma brucei | |
5-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | - |
Trypanosoma brucei | |
5-(3-chlorophenyl)-6-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | - |
Trypanosoma brucei | |
5-(4-fluorophenyl)-4-(2-methylpropoxy)-7H-pyrrolo[2,3-d]pyrimidin-2-amine | - |
Trypanosoma brucei | |
5-(4-fluorophenyl)-4-isopropyloxy-7H-pyrrolo[2,3-d]-pyrimidin-2-amine | - |
Trypanosoma brucei | |
5-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | - |
Trypanosoma brucei | |
5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | - |
Trypanosoma brucei | |
5-(phenylethynyl)-4-(1-pyrrolidinyl)-7H-pyrrolo[2,3-d]-pyrimidin-2-amine | - |
Trypanosoma brucei | |
5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | - |
Trypanosoma brucei | |
6-(4-bromophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | - |
Trypanosoma brucei | |
6-(4-fluorophenyl)-5-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | - |
Trypanosoma brucei | |
6-(4-fluorophenyl)-5-(4-methoxyphenyl)-N4,N4-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | - |
Trypanosoma brucei | |
6-(4-fluorophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | - |
Trypanosoma brucei | |
6-(4-fluorophenyl)-N~4~,N~4~-dimethyl-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | - |
Trypanosoma brucei | |
6-[4-(2-methylpropyl)phenyl]-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | - |
Trypanosoma brucei | |
6-[4-(methanesulfonyl)phenyl]-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | - |
Trypanosoma brucei | |
additional information | structure-based design and synthesis of 61 antiparasitic pyrrolopyrimidines targeting pteridine reductase 1, with input from crystal structures of 23 of these compounds complexed with enzyme PTR1, structure-activity relationships, inhibition mechanism, overview. Analysis of eight compounds sufficiently active in vivo evaluation in HEK cells, pharmacokinetic properties | Trypanosoma brucei | |
N-[3-(2,4-diamino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]methanesulfonamide | - |
Trypanosoma brucei | |
N-[3-(2-amino-5-cyano-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]methanesulfonamide | - |
Trypanosoma brucei | |
N4,N4-dimethyl-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | - |
Trypanosoma brucei | |
N4-cyclohexyl-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | - |
Trypanosoma brucei | |
N4-cyclohexyl-5-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | - |
Trypanosoma brucei |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
biopterin + 2 NADPH + 2 H+ | Trypanosoma brucei | - |
5,6,7,8-tetrahydrobiopterin + 2 NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
biopterin + 2 NADPH + 2 H+ | - |
Trypanosoma brucei | 5,6,7,8-tetrahydrobiopterin + 2 NADP+ | - |
? | |
biopterin + 2 NADPH + 2 H+ | substrate binding structure | Trypanosoma brucei | 5,6,7,8-tetrahydrobiopterin + 2 NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
pteridine reductase 1 | - |
Trypanosoma brucei |
PTR1 | - |
Trypanosoma brucei |
TbPTR1 | - |
Trypanosoma brucei |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | cofactor binding structure | Trypanosoma brucei |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000135 | - |
6-(4-bromophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.000137 | - |
2-amino-4-oxo-6-[(E)-2-phenylethenyl]-4,7-dihydro-3Hpyrrolo[2,3-d]pyrimidine-5-carbonitrile | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00016 | - |
2,4-diamino-6-[(E)-2-phenylethenyl]-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00019 | - |
5-(phenylethynyl)-4-(1-pyrrolidinyl)-7H-pyrrolo[2,3-d]-pyrimidin-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0002 | - |
2-amino-6-(3-formylphenyl)-4-(1-pyrrolidinyl)-7H-pyrrolo-[2,3-d]pyrimidine-5-carbonitrile | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0002 | - |
N4-cyclohexyl-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | in Creek's minimal medium, pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00023 | - |
N-[3-(2,4-diamino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]methanesulfonamide | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00023 | - |
2-amino-6-(4-bromophenyl)-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00024 | - |
2,4-diamino-6-[(Z)-2-phenylethenyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00024 | - |
6-(4-fluorophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00025 | - |
2-amino-5,6-bis(4-chlorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00026 | - |
5-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00027 | - |
2-amino-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00029 | - |
5-(3-chlorophenyl)-6-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00029 | - |
N4,N4-dimethyl-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | in Creek's minimal medium, pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0003 | - |
5,6-bis(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0003 | - |
6-(4-fluorophenyl)-5-(4-methoxyphenyl)-N4,N4-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | in Creek's minimal medium, pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00032 | - |
5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00035 | - |
N-[3-(2-amino-5-cyano-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]methanesulfonamide | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00035 | - |
2,4-diamino-6-[(Z)-2-(4-methylphenyl)ethenyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0004 | - |
5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00047 | - |
2-amino-5-(3-chlorophenyl)-6-(4-fluorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00048 | - |
5-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0005 | - |
2-amino-6-(4-fluorophenyl)-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00056 | - |
N4-cyclohexyl-5-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00058 | - |
6-(4-fluorophenyl)-5-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00058 | - |
6-[4-(2-methylpropyl)phenyl]-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00059 | - |
5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.000731 | - |
2-amino-6-[3-(methanesulfonyl)phenyl]-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00076 | - |
2-amino-5,6-bis(4-fluorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0008 | - |
2-amino-6-bromo-4-(1-pyrrolidinyl)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00095 | - |
2-amino-6-phenyl-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00106 | - |
2-amino-5-methyl-6-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00117 | - |
2-amino-5,6-diphenyl-3,7-dihydro-4H-pyrrolo[2,3-d]-pyrimidin-4-one | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0012 | - |
2-amino-5-(4-methylphenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0012 | - |
2-amino-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.00128 | - |
6-[4-(methanesulfonyl)phenyl]-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0013 | - |
2-amino-5-(4-fluorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.002 | 0.01 | 2-amino-5,6-bis(4-methylphenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.003317 | - |
2,4-diamino-6-bromo-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0042 | - |
4-(1-pyrrolidinyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0049 | - |
2,4-diamino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0073 | - |
2-amino-5-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0086 | - |
4-(thiomorpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.0088 | - |
2-amino-4-(thiomorpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | pH and temperature not specified in the publication | Trypanosoma brucei | |
0.01 | - |
2-amino-6-[4-(2-methylpropyl)phenyl]-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | above, pH and temperature not specified in the publication | Trypanosoma brucei | |
0.01 | - |
2-amino-6-[4-[3-(4-morpholinyl)propyl]phenyl]-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one trifluoroacetate | above, in Creek's minimal medium, pH and temperature not specified in the publication | Trypanosoma brucei | |
0.05 | - |
5-(4-fluorophenyl)-4-(2-methylpropoxy)-7H-pyrrolo[2,3-d]pyrimidin-2-amine | above, pH and temperature not specified in the publication | Trypanosoma brucei | |
0.075 | - |
2-amino-4-methoxy-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | above, pH and temperature not specified in the publication | Trypanosoma brucei | |
0.1 | - |
2-amino-4-[(propan-2-yl)oxy]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | above, pH and temperature not specified in the publication | Trypanosoma brucei | |
0.1 | - |
2-amino-4-(cyclopentyloxy)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | above, pH and temperature not specified in the publication | Trypanosoma brucei |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00008 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 6-(4-fluorophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.000083 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 6-(4-fluorophenyl)-5-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.00014 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2-amino-6-phenyl-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | |
0.00015 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 5,6-bis(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.00019 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 5,6-bis(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.00019 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 5-(3-chlorophenyl)-6-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.00025 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 6-(4-bromophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.00041 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2-amino-5,6-diphenyl-3,7-dihydro-4H-pyrrolo[2,3-d]-pyrimidin-4-one | |
0.00043 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2-amino-5,6-bis(4-methylphenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | |
0.00058 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.00061 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2-amino-6-(4-fluorophenyl)-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | |
0.00065 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 5-(phenylethynyl)-4-(1-pyrrolidinyl)-7H-pyrrolo[2,3-d]-pyrimidin-2-amine | |
0.00074 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2-amino-5,6-bis(4-fluorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | |
0.00077 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2-amino-5-(3-chlorophenyl)-6-(4-fluorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | |
0.00103 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2-amino-6-(4-fluorophenyl)-5-(4-methoxyphenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | |
0.00104 | - |
above, pH and temperature not specified in the publication | Trypanosoma brucei | 2-amino-4-(cyclopentyloxy)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | |
0.00131 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 5,6-bis(4-fluorophenyl)-N~4~,N~4~-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.00134 | - |
in Creek's minimal medium, pH and temperature not specified in the publication | Trypanosoma brucei | 6-(4-fluorophenyl)-N~4~,N~4~-dimethyl-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.00139 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 6-[4-(2-methylpropyl)phenyl]-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.00142 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 5-(4-fluorophenyl)-4-isopropyloxy-7H-pyrrolo[2,3-d]-pyrimidin-2-amine | |
0.00156 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2-amino-5,6-bis(4-chlorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | |
0.00178 | - |
in Creek's minimal medium, pH and temperature not specified in the publication | Trypanosoma brucei | N4-cyclohexyl-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.00202 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 5,6-bis(4-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.00213 | - |
above, pH and temperature not specified in the publication | Trypanosoma brucei | 2-amino-6-[4-(2-methylpropyl)phenyl]-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | |
0.00253 | - |
above, pH and temperature not specified in the publication | Trypanosoma brucei | 5-(4-fluorophenyl)-4-(2-methylpropoxy)-7H-pyrrolo[2,3-d]pyrimidin-2-amine | |
0.00308 | - |
in Creek's minimal medium, pH and temperature not specified in the publication | Trypanosoma brucei | 5,6-bis(4-chlorophenyl)-N~4~,N~4~-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.0032 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2-amino-6-(4-bromophenyl)-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | |
0.00343 | - |
in Creek's minimal medium, pH and temperature not specified in the publication | Trypanosoma brucei | 6-(4-fluorophenyl)-5-(4-methoxyphenyl)-N4,N4-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.00603 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | N-[3-(2,4-diamino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]methanesulfonamide | |
0.00611 | - |
in Creek's minimal medium, pH and temperature not specified in the publication | Trypanosoma brucei | N4,N4-dimethyl-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.00616 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 6-[4-(methanesulfonyl)phenyl]-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.0073 | - |
above, pH and temperature not specified in the publication | Trypanosoma brucei | 2-amino-4-[(propan-2-yl)oxy]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | |
0.00775 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2-amino-6-(3-formylphenyl)-4-(1-pyrrolidinyl)-7H-pyrrolo-[2,3-d]pyrimidine-5-carbonitrile | |
0.0104 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2-amino-5-methyl-6-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | |
0.0115 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | N~4~-cyclohexyl-5-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.01433 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2-amino-4-(thiomorpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | |
0.01447 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 5-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.01708 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2,4-diamino-6-[(Z)-2-(4-methylphenyl)ethenyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | |
0.0201 | - |
above, in Creek's minimal medium, pH and temperature not specified in the publication | Trypanosoma brucei | 2-amino-6-[4-[3-(4-morpholinyl)propyl]phenyl]-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one trifluoroacetate | |
0.02511 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2-amino-5-(4-fluorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | |
0.04101 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.05334 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2-amino-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | |
0.0624 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2,4-diamino-6-bromo-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | |
0.07252 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2,4-diamino-6-[(E)-2-phenylethenyl]-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile | |
0.08006 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 4-(thiomorpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine | |
0.09352 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 5-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.1 | - |
above, pH and temperature not specified in the publication | Trypanosoma brucei | 2-amino-6-[4-(methanesulfonyl)phenyl]-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | |
0.125 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2-amino-5-(4-methylphenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one | |
0.139 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2-amino-6-bromo-4-(1-pyrrolidinyl)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile | |
0.17 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2,4-diamino-6-[(Z)-2-phenylethenyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | |
0.17 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.34 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2-amino-4-(1-pyrrolidinyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | |
2.44 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2,4-diamino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | |
7.62 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2-amino-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one |
General Information | Comment | Organism |
---|---|---|
additional information | organization of the TbPTR1 active site, overview | Trypanosoma brucei |