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Literature summary for 1.5.1.33 extracted from

  • Khalaf, A.I.; Huggan, J.K.; Suckling, C.J.; Gibson, C.L.; Stewart, K.; Giordani, F.; Barrett, M.P.; Wong, P.E.; Barrack, K.L.; Hunter, W.N.
    Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1 (2014), J. Med. Chem., 57, 6479-6494 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
2,4-diamino-6-bromo-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
-
Trypanosoma brucei
2,4-diamino-6-[(E)-2-phenylethenyl]-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile
-
Trypanosoma brucei
2,4-diamino-6-[(Z)-2-(4-methylphenyl)ethenyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
-
Trypanosoma brucei
2,4-diamino-6-[(Z)-2-phenylethenyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
-
Trypanosoma brucei
2,4-diamino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
-
Trypanosoma brucei
2-amino-4-(1-pyrrolidinyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
-
Trypanosoma brucei
2-amino-4-(cyclopentyloxy)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
-
Trypanosoma brucei
2-amino-4-(thiomorpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
-
Trypanosoma brucei
2-amino-4-methoxy-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
-
Trypanosoma brucei
2-amino-4-oxo-6-[(E)-2-phenylethenyl]-4,7-dihydro-3Hpyrrolo[2,3-d]pyrimidine-5-carbonitrile
-
Trypanosoma brucei
2-amino-4-[(propan-2-yl)oxy]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
-
Trypanosoma brucei
2-amino-5,6-bis(4-chlorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
-
Trypanosoma brucei
2-amino-5,6-bis(4-fluorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
-
Trypanosoma brucei
2-amino-5,6-bis(4-methylphenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
-
Trypanosoma brucei
2-amino-5,6-diphenyl-3,7-dihydro-4H-pyrrolo[2,3-d]-pyrimidin-4-one
-
Trypanosoma brucei
2-amino-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
-
Trypanosoma brucei
2-amino-5-(3-chlorophenyl)-6-(4-fluorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
-
Trypanosoma brucei
2-amino-5-(4-fluorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
-
Trypanosoma brucei
2-amino-5-(4-methylphenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
-
Trypanosoma brucei
2-amino-5-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
-
Trypanosoma brucei
2-amino-5-methyl-6-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
-
Trypanosoma brucei
2-amino-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
-
Trypanosoma brucei
2-amino-6-(3-formylphenyl)-4-(1-pyrrolidinyl)-7H-pyrrolo-[2,3-d]pyrimidine-5-carbonitrile
-
Trypanosoma brucei
2-amino-6-(4-bromophenyl)-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
-
Trypanosoma brucei
2-amino-6-(4-fluorophenyl)-5-(4-methoxyphenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
-
Trypanosoma brucei
2-amino-6-(4-fluorophenyl)-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
-
Trypanosoma brucei
2-amino-6-bromo-4-(1-pyrrolidinyl)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile
-
Trypanosoma brucei
2-amino-6-phenyl-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
-
Trypanosoma brucei
2-amino-6-[3-(methanesulfonyl)phenyl]-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
-
Trypanosoma brucei
2-amino-6-[4-(2-methylpropyl)phenyl]-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
-
Trypanosoma brucei
2-amino-6-[4-(methanesulfonyl)phenyl]-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
-
Trypanosoma brucei
2-amino-6-[4-[3-(4-morpholinyl)propyl]phenyl]-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one trifluoroacetate
-
Trypanosoma brucei
4-(1-pyrrolidinyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine
-
Trypanosoma brucei
4-(thiomorpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine
-
Trypanosoma brucei
5,6-bis(4-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
-
Trypanosoma brucei
5,6-bis(4-chlorophenyl)-N~4~,N~4~-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
-
Trypanosoma brucei
5,6-bis(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
-
Trypanosoma brucei
5,6-bis(4-fluorophenyl)-N~4~,N~4~-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
-
Trypanosoma brucei
5,6-bis(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
-
Trypanosoma brucei
5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
-
Trypanosoma brucei
5-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
-
Trypanosoma brucei
5-(3-chlorophenyl)-6-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
-
Trypanosoma brucei
5-(4-fluorophenyl)-4-(2-methylpropoxy)-7H-pyrrolo[2,3-d]pyrimidin-2-amine
-
Trypanosoma brucei
5-(4-fluorophenyl)-4-isopropyloxy-7H-pyrrolo[2,3-d]-pyrimidin-2-amine
-
Trypanosoma brucei
5-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
-
Trypanosoma brucei
5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
-
Trypanosoma brucei
5-(phenylethynyl)-4-(1-pyrrolidinyl)-7H-pyrrolo[2,3-d]-pyrimidin-2-amine
-
Trypanosoma brucei
5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
-
Trypanosoma brucei
6-(4-bromophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
-
Trypanosoma brucei
6-(4-fluorophenyl)-5-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
-
Trypanosoma brucei
6-(4-fluorophenyl)-5-(4-methoxyphenyl)-N4,N4-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
-
Trypanosoma brucei
6-(4-fluorophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
-
Trypanosoma brucei
6-(4-fluorophenyl)-N~4~,N~4~-dimethyl-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
-
Trypanosoma brucei
6-[4-(2-methylpropyl)phenyl]-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
-
Trypanosoma brucei
6-[4-(methanesulfonyl)phenyl]-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
-
Trypanosoma brucei
additional information structure-based design and synthesis of 61 antiparasitic pyrrolopyrimidines targeting pteridine reductase 1, with input from crystal structures of 23 of these compounds complexed with enzyme PTR1, structure-activity relationships, inhibition mechanism, overview. Analysis of eight compounds sufficiently active in vivo evaluation in HEK cells, pharmacokinetic properties Trypanosoma brucei
N-[3-(2,4-diamino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]methanesulfonamide
-
Trypanosoma brucei
N-[3-(2-amino-5-cyano-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]methanesulfonamide
-
Trypanosoma brucei
N4,N4-dimethyl-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
-
Trypanosoma brucei
N4-cyclohexyl-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
-
Trypanosoma brucei
N4-cyclohexyl-5-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
-
Trypanosoma brucei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
biopterin + 2 NADPH + 2 H+ Trypanosoma brucei
-
5,6,7,8-tetrahydrobiopterin + 2 NADP+
-
?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
biopterin + 2 NADPH + 2 H+
-
Trypanosoma brucei 5,6,7,8-tetrahydrobiopterin + 2 NADP+
-
?
biopterin + 2 NADPH + 2 H+ substrate binding structure Trypanosoma brucei 5,6,7,8-tetrahydrobiopterin + 2 NADP+
-
?

Synonyms

Synonyms Comment Organism
pteridine reductase 1
-
Trypanosoma brucei
PTR1
-
Trypanosoma brucei
TbPTR1
-
Trypanosoma brucei

Cofactor

Cofactor Comment Organism Structure
NADPH cofactor binding structure Trypanosoma brucei

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000135
-
6-(4-bromophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine pH and temperature not specified in the publication Trypanosoma brucei
0.000137
-
2-amino-4-oxo-6-[(E)-2-phenylethenyl]-4,7-dihydro-3Hpyrrolo[2,3-d]pyrimidine-5-carbonitrile pH and temperature not specified in the publication Trypanosoma brucei
0.00016
-
2,4-diamino-6-[(E)-2-phenylethenyl]-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile pH and temperature not specified in the publication Trypanosoma brucei
0.00019
-
5-(phenylethynyl)-4-(1-pyrrolidinyl)-7H-pyrrolo[2,3-d]-pyrimidin-2-amine pH and temperature not specified in the publication Trypanosoma brucei
0.0002
-
2-amino-6-(3-formylphenyl)-4-(1-pyrrolidinyl)-7H-pyrrolo-[2,3-d]pyrimidine-5-carbonitrile pH and temperature not specified in the publication Trypanosoma brucei
0.0002
-
N4-cyclohexyl-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine in Creek's minimal medium, pH and temperature not specified in the publication Trypanosoma brucei
0.00023
-
N-[3-(2,4-diamino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]methanesulfonamide pH and temperature not specified in the publication Trypanosoma brucei
0.00023
-
2-amino-6-(4-bromophenyl)-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one pH and temperature not specified in the publication Trypanosoma brucei
0.00024
-
2,4-diamino-6-[(Z)-2-phenylethenyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile pH and temperature not specified in the publication Trypanosoma brucei
0.00024
-
6-(4-fluorophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine pH and temperature not specified in the publication Trypanosoma brucei
0.00025
-
2-amino-5,6-bis(4-chlorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one pH and temperature not specified in the publication Trypanosoma brucei
0.00026
-
5-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine pH and temperature not specified in the publication Trypanosoma brucei
0.00027
-
2-amino-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one pH and temperature not specified in the publication Trypanosoma brucei
0.00029
-
5-(3-chlorophenyl)-6-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine pH and temperature not specified in the publication Trypanosoma brucei
0.00029
-
N4,N4-dimethyl-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine in Creek's minimal medium, pH and temperature not specified in the publication Trypanosoma brucei
0.0003
-
5,6-bis(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine pH and temperature not specified in the publication Trypanosoma brucei
0.0003
-
6-(4-fluorophenyl)-5-(4-methoxyphenyl)-N4,N4-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine in Creek's minimal medium, pH and temperature not specified in the publication Trypanosoma brucei
0.00032
-
5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine pH and temperature not specified in the publication Trypanosoma brucei
0.00035
-
N-[3-(2-amino-5-cyano-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]methanesulfonamide pH and temperature not specified in the publication Trypanosoma brucei
0.00035
-
2,4-diamino-6-[(Z)-2-(4-methylphenyl)ethenyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile pH and temperature not specified in the publication Trypanosoma brucei
0.0004
-
5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine pH and temperature not specified in the publication Trypanosoma brucei
0.00047
-
2-amino-5-(3-chlorophenyl)-6-(4-fluorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one pH and temperature not specified in the publication Trypanosoma brucei
0.00048
-
5-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine pH and temperature not specified in the publication Trypanosoma brucei
0.0005
-
2-amino-6-(4-fluorophenyl)-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one pH and temperature not specified in the publication Trypanosoma brucei
0.00056
-
N4-cyclohexyl-5-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine pH and temperature not specified in the publication Trypanosoma brucei
0.00058
-
6-(4-fluorophenyl)-5-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine pH and temperature not specified in the publication Trypanosoma brucei
0.00058
-
6-[4-(2-methylpropyl)phenyl]-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine pH and temperature not specified in the publication Trypanosoma brucei
0.00059
-
5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine pH and temperature not specified in the publication Trypanosoma brucei
0.000731
-
2-amino-6-[3-(methanesulfonyl)phenyl]-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile pH and temperature not specified in the publication Trypanosoma brucei
0.00076
-
2-amino-5,6-bis(4-fluorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one pH and temperature not specified in the publication Trypanosoma brucei
0.0008
-
2-amino-6-bromo-4-(1-pyrrolidinyl)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile pH and temperature not specified in the publication Trypanosoma brucei
0.00095
-
2-amino-6-phenyl-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one pH and temperature not specified in the publication Trypanosoma brucei
0.00106
-
2-amino-5-methyl-6-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one pH and temperature not specified in the publication Trypanosoma brucei
0.00117
-
2-amino-5,6-diphenyl-3,7-dihydro-4H-pyrrolo[2,3-d]-pyrimidin-4-one pH and temperature not specified in the publication Trypanosoma brucei
0.0012
-
2-amino-5-(4-methylphenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one pH and temperature not specified in the publication Trypanosoma brucei
0.0012
-
2-amino-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one pH and temperature not specified in the publication Trypanosoma brucei
0.00128
-
6-[4-(methanesulfonyl)phenyl]-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine pH and temperature not specified in the publication Trypanosoma brucei
0.0013
-
2-amino-5-(4-fluorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one pH and temperature not specified in the publication Trypanosoma brucei
0.002 0.01 2-amino-5,6-bis(4-methylphenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one pH and temperature not specified in the publication Trypanosoma brucei
0.003317
-
2,4-diamino-6-bromo-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile pH and temperature not specified in the publication Trypanosoma brucei
0.0042
-
4-(1-pyrrolidinyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine pH and temperature not specified in the publication Trypanosoma brucei
0.0049
-
2,4-diamino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile pH and temperature not specified in the publication Trypanosoma brucei
0.0073
-
2-amino-5-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one pH and temperature not specified in the publication Trypanosoma brucei
0.0086
-
4-(thiomorpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine pH and temperature not specified in the publication Trypanosoma brucei
0.0088
-
2-amino-4-(thiomorpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile pH and temperature not specified in the publication Trypanosoma brucei
0.01
-
2-amino-6-[4-(2-methylpropyl)phenyl]-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one above, pH and temperature not specified in the publication Trypanosoma brucei
0.01
-
2-amino-6-[4-[3-(4-morpholinyl)propyl]phenyl]-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one trifluoroacetate above, in Creek's minimal medium, pH and temperature not specified in the publication Trypanosoma brucei
0.05
-
5-(4-fluorophenyl)-4-(2-methylpropoxy)-7H-pyrrolo[2,3-d]pyrimidin-2-amine above, pH and temperature not specified in the publication Trypanosoma brucei
0.075
-
2-amino-4-methoxy-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile above, pH and temperature not specified in the publication Trypanosoma brucei
0.1
-
2-amino-4-[(propan-2-yl)oxy]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile above, pH and temperature not specified in the publication Trypanosoma brucei
0.1
-
2-amino-4-(cyclopentyloxy)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile above, pH and temperature not specified in the publication Trypanosoma brucei

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00008
-
pH and temperature not specified in the publication Trypanosoma brucei 6-(4-fluorophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.000083
-
pH and temperature not specified in the publication Trypanosoma brucei 6-(4-fluorophenyl)-5-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.00014
-
pH and temperature not specified in the publication Trypanosoma brucei 2-amino-6-phenyl-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
0.00015
-
pH and temperature not specified in the publication Trypanosoma brucei 5,6-bis(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.00019
-
pH and temperature not specified in the publication Trypanosoma brucei 5,6-bis(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.00019
-
pH and temperature not specified in the publication Trypanosoma brucei 5-(3-chlorophenyl)-6-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.00025
-
pH and temperature not specified in the publication Trypanosoma brucei 6-(4-bromophenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.00041
-
pH and temperature not specified in the publication Trypanosoma brucei 2-amino-5,6-diphenyl-3,7-dihydro-4H-pyrrolo[2,3-d]-pyrimidin-4-one
0.00043
-
pH and temperature not specified in the publication Trypanosoma brucei 2-amino-5,6-bis(4-methylphenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
0.00058
-
pH and temperature not specified in the publication Trypanosoma brucei 5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.00061
-
pH and temperature not specified in the publication Trypanosoma brucei 2-amino-6-(4-fluorophenyl)-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
0.00065
-
pH and temperature not specified in the publication Trypanosoma brucei 5-(phenylethynyl)-4-(1-pyrrolidinyl)-7H-pyrrolo[2,3-d]-pyrimidin-2-amine
0.00074
-
pH and temperature not specified in the publication Trypanosoma brucei 2-amino-5,6-bis(4-fluorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
0.00077
-
pH and temperature not specified in the publication Trypanosoma brucei 2-amino-5-(3-chlorophenyl)-6-(4-fluorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
0.00103
-
pH and temperature not specified in the publication Trypanosoma brucei 2-amino-6-(4-fluorophenyl)-5-(4-methoxyphenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
0.00104
-
above, pH and temperature not specified in the publication Trypanosoma brucei 2-amino-4-(cyclopentyloxy)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.00131
-
pH and temperature not specified in the publication Trypanosoma brucei 5,6-bis(4-fluorophenyl)-N~4~,N~4~-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.00134
-
in Creek's minimal medium, pH and temperature not specified in the publication Trypanosoma brucei 6-(4-fluorophenyl)-N~4~,N~4~-dimethyl-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.00139
-
pH and temperature not specified in the publication Trypanosoma brucei 6-[4-(2-methylpropyl)phenyl]-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.00142
-
pH and temperature not specified in the publication Trypanosoma brucei 5-(4-fluorophenyl)-4-isopropyloxy-7H-pyrrolo[2,3-d]-pyrimidin-2-amine
0.00156
-
pH and temperature not specified in the publication Trypanosoma brucei 2-amino-5,6-bis(4-chlorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
0.00178
-
in Creek's minimal medium, pH and temperature not specified in the publication Trypanosoma brucei N4-cyclohexyl-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.00202
-
pH and temperature not specified in the publication Trypanosoma brucei 5,6-bis(4-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.00213
-
above, pH and temperature not specified in the publication Trypanosoma brucei 2-amino-6-[4-(2-methylpropyl)phenyl]-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
0.00253
-
above, pH and temperature not specified in the publication Trypanosoma brucei 5-(4-fluorophenyl)-4-(2-methylpropoxy)-7H-pyrrolo[2,3-d]pyrimidin-2-amine
0.00308
-
in Creek's minimal medium, pH and temperature not specified in the publication Trypanosoma brucei 5,6-bis(4-chlorophenyl)-N~4~,N~4~-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.0032
-
pH and temperature not specified in the publication Trypanosoma brucei 2-amino-6-(4-bromophenyl)-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
0.00343
-
in Creek's minimal medium, pH and temperature not specified in the publication Trypanosoma brucei 6-(4-fluorophenyl)-5-(4-methoxyphenyl)-N4,N4-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.00603
-
pH and temperature not specified in the publication Trypanosoma brucei N-[3-(2,4-diamino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]methanesulfonamide
0.00611
-
in Creek's minimal medium, pH and temperature not specified in the publication Trypanosoma brucei N4,N4-dimethyl-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.00616
-
pH and temperature not specified in the publication Trypanosoma brucei 6-[4-(methanesulfonyl)phenyl]-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.0073
-
above, pH and temperature not specified in the publication Trypanosoma brucei 2-amino-4-[(propan-2-yl)oxy]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.00775
-
pH and temperature not specified in the publication Trypanosoma brucei 2-amino-6-(3-formylphenyl)-4-(1-pyrrolidinyl)-7H-pyrrolo-[2,3-d]pyrimidine-5-carbonitrile
0.0104
-
pH and temperature not specified in the publication Trypanosoma brucei 2-amino-5-methyl-6-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
0.0115
-
pH and temperature not specified in the publication Trypanosoma brucei N~4~-cyclohexyl-5-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.01433
-
pH and temperature not specified in the publication Trypanosoma brucei 2-amino-4-(thiomorpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.01447
-
pH and temperature not specified in the publication Trypanosoma brucei 5-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.01708
-
pH and temperature not specified in the publication Trypanosoma brucei 2,4-diamino-6-[(Z)-2-(4-methylphenyl)ethenyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.0201
-
above, in Creek's minimal medium, pH and temperature not specified in the publication Trypanosoma brucei 2-amino-6-[4-[3-(4-morpholinyl)propyl]phenyl]-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one trifluoroacetate
0.02511
-
pH and temperature not specified in the publication Trypanosoma brucei 2-amino-5-(4-fluorophenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
0.04101
-
pH and temperature not specified in the publication Trypanosoma brucei 5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.05334
-
pH and temperature not specified in the publication Trypanosoma brucei 2-amino-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
0.0624
-
pH and temperature not specified in the publication Trypanosoma brucei 2,4-diamino-6-bromo-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.07252
-
pH and temperature not specified in the publication Trypanosoma brucei 2,4-diamino-6-[(E)-2-phenylethenyl]-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile
0.08006
-
pH and temperature not specified in the publication Trypanosoma brucei 4-(thiomorpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine
0.09352
-
pH and temperature not specified in the publication Trypanosoma brucei 5-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.1
-
above, pH and temperature not specified in the publication Trypanosoma brucei 2-amino-6-[4-(methanesulfonyl)phenyl]-5-phenyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
0.125
-
pH and temperature not specified in the publication Trypanosoma brucei 2-amino-5-(4-methylphenyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
0.139
-
pH and temperature not specified in the publication Trypanosoma brucei 2-amino-6-bromo-4-(1-pyrrolidinyl)-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonitrile
0.17
-
pH and temperature not specified in the publication Trypanosoma brucei 2,4-diamino-6-[(Z)-2-phenylethenyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
0.17
-
pH and temperature not specified in the publication Trypanosoma brucei 5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
0.34
-
pH and temperature not specified in the publication Trypanosoma brucei 2-amino-4-(1-pyrrolidinyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
2.44
-
pH and temperature not specified in the publication Trypanosoma brucei 2,4-diamino-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
7.62
-
pH and temperature not specified in the publication Trypanosoma brucei 2-amino-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

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