Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dihydrobiopterin | inhibits the enzyme at high substrate concentrations | Leishmania major | |
dihydrobiopterin | inhibits the enzyme at high substrate concentrations | Trypanosoma brucei | |
quinonoid 6,7-dimethyl-7,8-dihydropterin | - |
Leishmania major | |
quinonoid 6,7-dimethyl-7,8-dihydropterin | - |
Trypanosoma brucei | |
quinonoid dihydrobiopterin | - |
Leishmania major | |
quinonoid dihydrobiopterin | - |
Trypanosoma brucei |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000294 | - |
dihydrobiopterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Trypanosoma brucei | |
0.0032 | - |
dihydrobiopterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Leishmania major | |
0.0036 | - |
quinonoid dihydrobiopterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Trypanosoma brucei | |
0.0103 | - |
quinonoid dihydrobiopterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Leishmania major | |
0.0166 | - |
quinonoid 6,7-dimethyl-7,8-dihydropterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Trypanosoma brucei | |
0.021 | - |
quinonoid 6,7-dimethyl-7,8-dihydropterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Leishmania major |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Trypanosoma brucei | 5829 | - |
cytosol | - |
Leishmania major | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania major | - |
- |
- |
Trypanosoma brucei | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
biopterin + NADPH + H+ | - |
Trypanosoma brucei | dihydrobiopterin + NADP+ | - |
? | |
biopterin + NADPH + H+ | - |
Leishmania major | dihydrobiopterin + NADP+ | - |
? | |
dihydrobiopterin + NADPH + H+ | - |
Trypanosoma brucei | 5,6,7,8-tetrahydrobiopterin + NADP+ | - |
? | |
dihydrobiopterin + NADPH + H+ | - |
Leishmania major | 5,6,7,8-tetrahydrobiopterin + NADP+ | - |
? | |
quinonoid 6,7-dimethyl-7,8-dihydropterin + NADPH + H+ | - |
Trypanosoma brucei | ? | - |
? | |
quinonoid 6,7-dimethyl-7,8-dihydropterin + NADPH + H+ | - |
Leishmania major | ? | - |
? | |
quinonoid dihydrobiopterin + NADPH + H+ | - |
Trypanosoma brucei | tetrahydrobiopterin + NADP+ | - |
? | |
quinonoid dihydrobiopterin + NADPH + H+ | - |
Leishmania major | tetrahydrobiopterin + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
pteridine reductase 1 | - |
Trypanosoma brucei |
pteridine reductase 1 | - |
Leishmania major |
PTR1 | - |
Trypanosoma brucei |
PTR1 | - |
Leishmania major |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.05 | - |
dihydrobiopterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Trypanosoma brucei | |
0.43 | - |
quinonoid 6,7-dimethyl-7,8-dihydropterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Trypanosoma brucei | |
0.44 | - |
quinonoid 6,7-dimethyl-7,8-dihydropterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Leishmania major | |
0.54 | - |
quinonoid dihydrobiopterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Trypanosoma brucei | |
0.57 | - |
dihydrobiopterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Leishmania major | |
1.84 | - |
quinonoid dihydrobiopterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Leishmania major |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | 8 | - |
Trypanosoma brucei |
5.5 | 8 | - |
Leishmania major |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4 | 9 | - |
Trypanosoma brucei |
4 | 9 | - |
Leishmania major |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Trypanosoma brucei | |
NADPH | - |
Leishmania major |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00015 | - |
dihydrobiopterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Leishmania major | |
0.00116 | - |
dihydrobiopterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Trypanosoma brucei | |
0.00122 | - |
quinonoid dihydrobiopterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Leishmania major | |
0.00314 | - |
quinonoid dihydrobiopterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Trypanosoma brucei | |
0.0922 | - |
quinonoid 6,7-dimethyl-7,8-dihydropterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Leishmania major | |
0.475 | - |
quinonoid 6,7-dimethyl-7,8-dihydropterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Trypanosoma brucei |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme has an essential and dual role in pterin metabolism | Trypanosoma brucei |
physiological function | the enzyme has an essential and dual role in pterin metabolism | Leishmania major |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
21 | - |
quinonoid 6,7-dimethyl-7,8-dihydropterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Leishmania major | |
26 | - |
quinonoid 6,7-dimethyl-7,8-dihydropterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Trypanosoma brucei | |
160 | - |
quinonoid dihydrobiopterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Trypanosoma brucei | |
170 | - |
dihydrobiopterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Leishmania major | |
180 | - |
quinonoid dihydrobiopterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Leishmania major | |
1700 | - |
dihydrobiopterin | in 50 mM HEPES buffer, pH 7.4, at 25°C | Trypanosoma brucei |