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Literature summary for 1.5.1.33 extracted from

  • Mpamhanga, C.P.; Spinks, D.; Tulloch, L.B.; Shanks, E.J.; Robinson, D.A.; Collie, I.T.; Fairlamb, A.H.; Wyatt, P.G.; Frearson, J.A.; Hunter, W.N.; Gilbert, I.H.; Brenk, R.
    One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening (2009), J. Med. Chem., 52, 4454-4465.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei O76290
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Trypanosoma brucei

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydrobiopterin + NADPH
-
Trypanosoma brucei 5,6,7,8-tetrahydrobiopterin + NADP+
-
r

Synonyms

Synonyms Comment Organism
pteridine reductase 1
-
Trypanosoma brucei
PTR1
-
Trypanosoma brucei

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.01
-
2-amino-6-chloro-benzimidazole
-
Trypanosoma brucei
0.021
-
2,4-diaminoquinazoline called compound 2 Trypanosoma brucei
0.141
-
2,4-diaminopyrimidine called compound 3 Trypanosoma brucei