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Literature summary for 1.5.1.33 extracted from

  • Hardy, L.W.; Matthews, W.; Nare, B.; Beverley, S.M.
    Biochemical and genetic tests for inhibitors of Leishmania pteridine pathways (1997), Exp. Parasitol., 87, 157-169.
    View publication on PubMed

Application

Application Comment Organism
pharmacology successful antifolate chemotherapy in Leishmania will have to target simultaneously both pterine reductase 1 and dihydrofolate reductase-thymidylate synthase Leishmania major

Inhibitors

Inhibitors Comment Organism Structure
2,4-Diaminopteridines overview Leishmania major
2,4-diaminopyrimidines
-
Leishmania major
2,4-Diaminoquinazolines overview Leishmania major
Pteridines and analogs, overview Leishmania major

Organism

Organism UniProt Comment Textmining
Leishmania major
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Biopterin + NADPH
-
Leishmania major 5,6,7,8-Tetrahydrobiopterin + NADP+
-
?
Dihydrobiopterin + NADPH
-
Leishmania major ?
-
?