Application | Comment | Organism |
---|---|---|
pharmacology | successful antifolate chemotherapy in Leishmania will have to target simultaneously both pterine reductase 1 and dihydrofolate reductase-thymidylate synthase | Leishmania major |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dihydrobiopterin | substrate inhibition | Leishmania major | |
dihydrofolate | substrate inhibition | Leishmania major | |
additional information | - |
Leishmania major |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.012 | - |
NADPH | NADPH | Leishmania major |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
30000 | - |
4 * 30000 | Leishmania major |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania major | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
5,6,7,8-tetrahydrobiopterin + 2 NADP+ = biopterin + 2 NADPH + 2 H+ | ordered sequential reaction mechanism | Leishmania major |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Biopterin + NADPH | - |
Leishmania major | 5,6,7,8-Tetrahydrobiopterin + NADP+ | - |
? | |
Dihydrobiopterin + NADPH | - |
Leishmania major | ? | - |
? | |
Dihydrofolate + NADPH | - |
Leishmania major | 5,6,7,8-Tetrahydrofolate + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | 4 * 30000 | Leishmania major |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.7 | - |
biopterin as substrate | Leishmania major |
6 | - |
folate as substrate | Leishmania major |