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Literature summary for 1.5.1.3 extracted from

  • Erickson, J.S.; Mathews, C.K.
    Dihydrofolate reductases of Escherichia coli and bacteriophage Tr. A spectrofluorometric study (1973), Biochemistry, 12, 372-380.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
aminopterin
-
Escherichia coli
aminopterin
-
Tequatrovirus T4
Cl-
-
Escherichia coli
Cl-
-
Tequatrovirus T4
ClO4-
-
Escherichia coli
ClO4-
-
Tequatrovirus T4
F-
-
Escherichia coli
F-
-
Tequatrovirus T4
methotrexate
-
Escherichia coli
methotrexate
-
Tequatrovirus T4
N10-formylaminopterin competitive against 7,8-dihydrofolate and noncompetitive against NADPH Tequatrovirus T4
SCN-
-
Escherichia coli
SCN-
-
Tequatrovirus T4

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Escherichia coli
additional information
-
additional information
-
Tequatrovirus T4
0.0023
-
7,8-dihydrofolate
-
Tequatrovirus T4
0.018
-
NADPH
-
Tequatrovirus T4

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
22500
-
B, SDS-PAGE Escherichia coli
29000
-
SDS-PAGE Tequatrovirus T4

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli MB 1428 / B / ATCC 11303
-
-
-
Tequatrovirus T4
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli
-
Tequatrovirus T4

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Escherichia coli
additional information
-
-
Tequatrovirus T4

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7,8-dihydrofolate + NADPH + H+
-
Tequatrovirus T4 5,6,7,8-tetrahydrofolate + NADP+
-
r

Subunits

Subunits Comment Organism
monomer 1 * 29000, SDS-PAGE Tequatrovirus T4
monomer 1 * 22500, SDS-PAGE Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Escherichia coli
NADPH A-side specific Tequatrovirus T4

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00018
-
N10-formylaminopterin
-
Tequatrovirus T4